1.
Cancer Res
; 42(3): 791-8, 1982 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-7059977
RESUMO
Ethyl 5-amino-1,2-dihydro-3-[N-methylanilino)methyl]pyrido[3,4-b]pyrazin-7-ylcarbamate (NSC 181928) is reported to be active against several experimental neoplasms. The experimental data obtained in the present study indicate that it causes the accumulation of cells at mitosis with both cultured cells and ascites cancer cells in vivo. This effect was observed with L1210, P388, colon cancer 26, colon cancer 38, and H.Ep. 2 cells in culture and with L1210 cells and P388 cells in mice. The agent was also active in vitro and in vivo against a line of leukemia P388 cells that are resistant to vincristine.
Assuntos
Antineoplásicos/farmacologia , Divisão Celular/efeitos dos fármacos , Neoplasias Experimentais/patologia , Pirazinas/farmacologia , Animais , Linhagem Celular , Sobrevivência Celular/efeitos dos fármacos , DNA/biossíntese , Relação Dose-Resposta a Droga , Avaliação Pré-Clínica de Medicamentos , Metotrexato/farmacologia , Camundongos , Camundongos Endogâmicos BALB C , Mitose/efeitos dos fármacos , Transplante de Neoplasias
2.
Biochem Pharmacol
; 30(16): 2381-4, 1981 Aug 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-7295351