Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Respirology ; 19(8): 1097-105, 2014 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-25186813

RESUMO

The number of lung transplants performed globally continues to increase year after year. Despite this growing experience, long-term outcomes following lung transplantation continue to fall far short of that described in other solid-organ transplant settings. Chronic lung allograft dysfunction (CLAD) remains common and is the end result of exposure to a multitude of potentially injurious insults that include alloreactivity and infection among others. Central to any description of the clinical performance of the transplanted lung is an assessment of its physiology by pulmonary function testing. Spirometry and the evaluation of forced expiratory volume in 1 s and forced vital capacity, remain core indices that are measured as part of routine clinical follow-up. Spirometry, while reproducible in detecting lung allograft dysfunction, lacks specificity in differentiating the different complications of lung transplantation such as rejection, infection and bronchiolitis obliterans. However, interpretation of spirometry is central to defining the different 'chronic rejection' phenotypes. It is becoming apparent that the maximal lung function achieved following transplantation, as measured by spirometry, is influenced by a number of donor and recipient factors as well as the type of surgery performed (single vs double vs lobar lung transplant). In this review, we discuss the wide range of variables that need to be considered when interpreting lung function testing in lung transplant recipients. Finally, we review a number of novel measurements of pulmonary function that may in the future serve as better biomarkers to detect and diagnose the cause of the failing lung allograft.


Assuntos
Função Retardada do Enxerto/diagnóstico , Pneumopatias , Transplante de Pulmão , Pulmão/fisiopatologia , Adulto , Bronquiolite Obliterante/etiologia , Bronquiolite Obliterante/fisiopatologia , Criança , Sobrevivência de Enxerto , Humanos , Pneumopatias/classificação , Pneumopatias/diagnóstico , Pneumopatias/fisiopatologia , Pneumopatias/cirurgia , Transplante de Pulmão/efeitos adversos , Transplante de Pulmão/métodos , Testes de Função Respiratória/métodos , Espirometria/métodos , Transplantes/fisiopatologia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...