Assuntos
Agranulocitose/diagnóstico , Neutropenia/diagnóstico , Adolescente , Adulto , Idoso , Células Sanguíneas/patologia , Medula Óssea/patologia , Criança , Pré-Escolar , Doença Crônica , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neutropenia/sangue , Neutropenia/terapia , Prednisona/uso terapêutico , EsplenectomiaRESUMO
Our present knowledge of Hodgkin's disease is briefly reviewed and the prognostic importance of histologic subtype and stage is demonstrated. Today's staging methods and the indications for laparoscopy and laparotomy with splenectomy are discussed. The indications and results of radiotherapy and/or chemotherapy are summarized. Roughly half the patients in stages III B, IV A and IV B survive 5 to 10 years after diagnosis without evidence of disease.
Assuntos
Doença de Hodgkin , Quimioterapia Combinada , Doença de Hodgkin/tratamento farmacológico , Humanos , Laparoscopia , Expectativa de Vida , Mecloretamina/uso terapêutico , Estadiamento de Neoplasias , Prednisona/uso terapêutico , Procarbazina/uso terapêutico , Esplenectomia , Vincristina/uso terapêuticoRESUMO
Urinary and serum colony-stimulating factor (CSF) levels were measured in 11 patients with chronic idiopathic neutropenia without infections and in 10 normal individuals. Urinary CSF output was determined using mouse marrow target cells, and serum CSF activity was assayed with human marrow target cells by the double agar layer technique. Using these methods, there was no significant difference between CSF levels of neutropenic and normal subjects. These data indicate that CSF levels are not inversely related to the blood neutrophil count in chronic idiopathic neutropenia and suggest that CSF is not a hormone regulating the blood neutrophil count in a manner analogous to the erythropoietin regulation of circulating erythrocyte levels.
