1.
Bioorg Med Chem Lett
; 21(5): 1394-8, 2011 Mar 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21292480
RESUMO
We describe the synthesis and potency of a novel series of N-substituted 2-phenyl- and 2-methyl-2-phenyl-1,4-diaminobutane- based CCR5 antagonists. Compounds 7a and 12f were found to be potent in anti-HIV assays and bioavailable in the low-dose rat PK model.