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1.
J Healthc Qual ; 34(5): 39-47; quiz 48-9, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22860887

RESUMO

To achieve sustainable reductions in healthcare-associated infections (HAIs), the University of Washington Medical Center (UWMC) deployed a collaborative, systems-level initiative. With the sponsorship of senior leadership, multidisciplinary teams were established to address healthcare-associated methicillin-resistant Staphylococcus aureus (MRSA), central-line-associated bloodstream infections (CLABSI), ventilator-associated pneumonia (VAP), and respiratory virus infections. The goal of the initiative was to eliminate these four HAIs among medical center inpatients by 2012. In the first 24 months of the project, the number of healthcare-associated MRSA cases decreased 58%; CLABSI cases decreased 54%. Staff and provider compliance with infection prevention measures improved and remained strong, for example, 96% compliance with hand hygiene, 98% compliance with the recommended influenza vaccination program, and 100% compliance with the VAP bundle. Achieving these results required an array of coordinated, systems-level interventions. Critical project success factors were believed to include creating organizational alignment by declaring eliminating HAIs as an organizational breakthrough goal, having the organization's executive leadership highly engaged in the project, coordination by an experienced and effective project leader and manager, collaboration by multidisciplinary project teams, and promoting transparency of results across the organization.


Assuntos
Bacteriemia/prevenção & controle , Infecções Relacionadas a Cateter/prevenção & controle , Comportamento Cooperativo , Infecção Hospitalar/prevenção & controle , Controle de Infecções/métodos , Staphylococcus aureus Resistente à Meticilina , Pneumonia Associada à Ventilação Mecânica/prevenção & controle , Infecções Respiratórias/prevenção & controle , Infecções Respiratórias/virologia , Infecções Estafilocócicas/prevenção & controle , Humanos , Modelos Organizacionais , Objetivos Organizacionais , Washington/epidemiologia
2.
Cancer ; 98(5): 1039-47, 2003 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-12942573

RESUMO

BACKGROUND: The objective of the current study was to compare the efficacy and safety of imipenem and cefepime in the treatment of adult patients with cancer who had fever and neutropenia requiring hospitalization according to Infectious Disease Society of America criteria. METHODS: In the current prospective randomized clinical trial at a university-affiliated tertiary cancer center, adult patients with cancer who had fever (> or = 38.3 degrees C or > or = 38.0 degrees C for > 2 hours) and neutropenia (< or = 500/mm(3) or < 1000/mm(3) but declining) requiring hospitalization were randomized to receive either cefepime or imipenem. Vancomycin or amikacin was added on suspicion of gram-positive or gram-negative bacterial infection, respectively. RESULTS: Patients who received an imipenem regimen or a cefepime regimen were comparable in terms of age, gender, underlying malignancy, prior transplantation, degree and trend of neutropenia, and presence of central venous catheters (P > or = 0.3). An intent-to-treat analysis showed a 68% response rate to the imipenem regimen, compared with a 75% response rate to the cefepime regimen (P = 0.2). The rates of antibiotic-related adverse events and superinfections also were comparable (P = 0.6). There was no difference in response among patients who received imipenem or cefepime alone compared with patients who also received vancomycin or amikacin (P = 1.0). Leukemia was the only independent risk factor associated with a poor outcome (odds ratio, 4.6; 95% confidence interval, 1.9-10.7; P < 0.0001). CONCLUSIONS: Imipenem and cefepime had similar efficacy and safety profiles in the treatment of adult cancer patients with fever and neutropenia who required hospitalization. The addition of either vancomycin or amikacin may not be necessary.


Assuntos
Antibacterianos/farmacologia , Cefalosporinas/farmacologia , Febre/tratamento farmacológico , Febre/etiologia , Imipenem/farmacologia , Neoplasias/complicações , Neutropenia/tratamento farmacológico , Neutropenia/etiologia , Guias de Prática Clínica como Assunto , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Amicacina/administração & dosagem , Antibacterianos/administração & dosagem , Antibacterianos/efeitos adversos , Infecções Bacterianas/etiologia , Infecções Bacterianas/prevenção & controle , Cateterismo Venoso Central , Cefepima , Cefalosporinas/administração & dosagem , Cefalosporinas/efeitos adversos , Feminino , Febre/complicações , Hospitalização , Humanos , Imipenem/administração & dosagem , Imipenem/efeitos adversos , Masculino , Pessoa de Meia-Idade , Neutropenia/complicações , Estudos Prospectivos , Fatores de Risco , Vancomicina/administração & dosagem
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