Assuntos
Dependovirus/metabolismo , Proteoglicanas de Heparan Sulfato/metabolismo , Pulmão/virologia , Receptores Virais/metabolismo , Polaridade Celular , Células Epiteliais/citologia , Células Epiteliais/metabolismo , Células Epiteliais/virologia , Humanos , Pulmão/citologia , Recombinação GenéticaRESUMO
We report the novel occurrence of an erroneous automated total and differential white blood cell count on a blood sample obtained by traumatic femoral venepuncture, caused by contamination of the blood sample with subcutaneous adipose tissue. The erroneous counts were observed on a Bayer-Technicon H2 analyser while counts on a Coulter GenS, were much less affected. Characteristic scatter plots from both instruments are illustrated.
Assuntos
Erros de Diagnóstico , Veia Femoral , Contagem de Leucócitos , Idoso , Coleta de Amostras Sanguíneas/efeitos adversos , Reações Falso-Positivas , Feminino , Humanos , Punções/efeitos adversosRESUMO
In chronic myeloid leukaemia (CML), treatment with interferon alpha IFN-alpha results in loss of the Ph' chromosome in a significant proportion of patients. Most cytogenetic responses occur early at a median of 9 months after initiation of treatment and failure to detect a cytogenetic response within a predetermined period may be a reason for IFN-alpha withdrawal. We report a patient in whom IFN-alpha dosage was initially severely limited by bone marrow suppression but in whom continuing treatment led to a first cytogenetic response only after 53 months. Increasing Ph' negativity over a further 2 years was associated with improving haematological tolerance which permitted IFN-alpha dose escalation and complete cytogenetic remission was achieved at 7 years after diagnosis. This remission has been sustained and has thus followed the most delayed cytogenetic response to IFN-alpha so far reported.
