RESUMO
The aim of the present study was to prepare spirulina polysaccharide (PSP) into an oral nanoemulsion (NE) with the aim of improving its oral bioavailability and prolonging its sustained release effect. The PSPNE was prepared through a phase transformation method, and its formulation components were screened through the use of a pseudoternary phase diagram. The optimal formulation of PSPNE was determined to be: 11.9% Span 80, 6.0% Tween-80, 9.0% ethanol, 62.8% soybean oil, and 10.3% PSP aqueous solution. The prepared PSPNE was clear and transparent, had a uniform color and spherical morphology, exhibited stability and no adhesion. The average particle size was 79.93±19 nm, the polydispersity index was 0.185±0.04 (n=3), and the entrapment rate was 62%. Smallanimal imaging results showed that the prepared PSPNE exhibited a sustained release and tissue effect in contrast to the PSP aqueous solution. The present study showed that the prepared PSPNE not only exhibited a sustained release and tissue effect in contrast to the PSP aqueous solution, but also had superior performance in terms of antitumor and antioxidant effects.