Assuntos
Mesoridazina/uso terapêutico , Adulto , Idoso , Comportamento/efeitos dos fármacos , Peso Corporal/efeitos dos fármacos , Ensaios Clínicos como Assunto , Feminino , Humanos , Masculino , Processos Mentais/efeitos dos fármacos , Mesoridazina/farmacologia , Pessoa de Meia-Idade , Filmes Cinematográficos , Transtornos dos Movimentos/tratamento farmacológicoRESUMO
A spectral analysis technique for quantifying dyskinesia in patients with diagnosis of Hungtington's Disease (chorea) (H.D.) is described. Spectral analysis involves computation of the magnitude of abnormal involuntary movements (AIMS) and of their distribution in frequency. It has the advantage of providing an objective measure of such movements. Three H.D. patients under different drug regimens and three age-matched controls have been evaluated and representative time records and power spectra are presented. Analysis established marked differences in the amplitude and shape of the normal and patient spectra. In addition, spectral analysis proved sensitive to differences in drug treatments among patients suggesting its additional use in evaluating the efficacy of therapeutic agents in the treatment of movement disorders.
Assuntos
Doença de Huntington/diagnóstico , Adulto , Idoso , Diazepam/uso terapêutico , Haloperidol/uso terapêutico , Humanos , Doença de Huntington/tratamento farmacológico , Doença de Huntington/fisiopatologia , Mesoridazina/uso terapêutico , Métodos , Pessoa de Meia-Idade , Transtornos dos Movimentos/diagnóstico , Proclorperazina/uso terapêutico , Fatores de Tempo , Triexifenidil/uso terapêuticoAssuntos
Cicloexanos/análogos & derivados , Ácidos Mandélicos/análogos & derivados , Vasodilatadores/metabolismo , Animais , Encéfalo/metabolismo , Cicloexanos/metabolismo , Diafragma/metabolismo , Mucosa Gástrica/metabolismo , Injeções Intraperitoneais , Rim/metabolismo , Fígado/metabolismo , Pulmão/metabolismo , Masculino , Ácidos Mandélicos/administração & dosagem , Ácidos Mandélicos/sangue , Ácidos Mandélicos/metabolismo , Ácidos Mandélicos/urina , Miocárdio/metabolismo , Ratos , Contagem de Cintilação , Baço/metabolismo , Fatores de Tempo , Trítio , Vasodilatadores/administração & dosagem , Vasodilatadores/sangue , Vasodilatadores/urinaRESUMO
The report presents a method developed to analyze strip chart records generated by a system previously described and termed cineseismography which makes available quantitative records of abnormal involuntary movements in the human. In this report, method for converting measurements made on the strip chart record is described. Application of the method is made in three cases with diagnosis of Huntington's disease (chorea). Case histories are presented for each subject detailing the medications and dosage, and the quantitative data together with the histograms derived are provided. Preliminary trials indicate that movement decomposition, as in ataxia, can also be detected and quantified.