1.
Chem Commun (Camb)
; 50(89): 13801-4, 2014 Nov 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25253534
RESUMO
A specialized kinetic analysis of real-time hyperpolarized [1,1,2,2-D4, 1-(13)C]choline (13)C-magnetic resonance spectroscopy enabled the determination of initial rates of metabolic enzyme activity (choline oxidase), enzyme-substrate affinity (Km), and inhibition. In a clinical MRI scanner, metabolite levels lower than 16 µM were detected at a temporal resolution of 1 s.
