RESUMO
The title compound, a metabolite of 4,5,6,7-tetrahydrobenzo[b]thien-4-ylurea, was synthesized and found to be an effective growth promoter in sheep, mice, and rats. In sheep it gave over a 6-week growth period at 15 and 60 ppm in the diet an economically and statistically significant growth response.
Assuntos
Peso Corporal/efeitos dos fármacos , Substâncias de Crescimento/síntese química , Compostos de Fenilureia/farmacologia , Tiofenos/farmacologia , Animais , Camundongos , Compostos de Fenilureia/síntese química , Ratos , Ovinos , Tiofenos/síntese químicaRESUMO
A 28-year-old baker with 13 years of occupational experience has developed, over the past several years, sinusitis, rhinitis, contact dermatitis, and asthma. Clinically, all of his symptoms were felt to be related to occupational exposure. Immunologic evaluation consisted of the following tests: intradermal skin testing, leukocyte histamine release, total serum IgE, PK transfer with immunoadsorption, and specific antigen bronchial challenge. Analysis of results would tend to implicate a type I, IgE-mediated immunologic reaction.
