1.
2.
Pharmazie
; 46(6): 424-6, 1991 Jun.
Artigo
em Alemão
| MEDLINE
| ID: mdl-1763120
RESUMO
A well known side effect of the long-term therapy with phenytoin is gum hyperplasia. 1-Acyl compounds and esters of the p-hydroxymetabolite with aliphatic and aromatic carboxylic acids were synthesized as potential prodrugs for therapeutic use if the neoformation of connective tissue is intended. The compounds were characterized by there physico-chemical constants and the absorption was proofed by a buccal test.
Assuntos
Fenitoína/análogos & derivados , Fenitoína/administração & dosagem , Absorção , Administração Bucal , Hidrólise , Fenitoína/farmacocinética , Pró-Fármacos/síntese química , Solubilidade
3.
Pharmazie
; 42(7): 452-5, 1987 Jul.
Artigo
em Alemão
| MEDLINE
| ID: mdl-3671469
RESUMO
An in-vitro model is presented which consists on several membrane Layers. The penetration of drugs from the ointment bases into these membrane Layers is observed. By combination of different membranes this system can be varied. In model calculations the resulting conditions are demonstrated.