Assuntos
Asma/imunologia , Hipersensibilidade Tardia/diagnóstico , Testes Intradérmicos/métodos , Testes Cutâneos/métodos , Adolescente , Adulto , Antígenos de Bactérias/administração & dosagem , Antígenos de Bactérias/imunologia , Antígenos de Fungos/administração & dosagem , Antígenos de Fungos/imunologia , Feminino , Humanos , Hipersensibilidade Tardia/etiologia , Imunidade Celular , Masculino , Pessoa de Meia-IdadeRESUMO
The study was undertaken to compare the protective action of HC 20-511 (Ketotifen) and disodium cromoglycate (Intal) in patients with the atopic form of asthma. A total of 50 asthmatics, 26 men and 24 women, aged 14 to 45 were examined by a double-blind controlled method. In the group examined, both Ketotifen and Intal were administered in 25 patients during 12 weeks. Ketotifen was highly effective in 14 patients (56.0 percent) while the results of treatment by Intal were highly effective in 19 patients (76.0 per cent). The tolerance to Ketotifen and Intal was excellent or good, respectively in 88 per cent and 100 per cent of treated persons. In the authors opinion, Ketotifen and Intal have a valuable protective effect in atopic asthma cases, but both are less effective in patients with recurrent infections of the respiratory tract.
Assuntos
Asma/tratamento farmacológico , Cromolina Sódica/uso terapêutico , Cetotifeno/uso terapêutico , Adolescente , Adulto , Asma/etiologia , Asma/prevenção & controle , Ensaios Clínicos como Assunto , Método Duplo-Cego , Feminino , Humanos , Hipersensibilidade Imediata/complicações , Masculino , Pessoa de Meia-Idade , Distribuição Aleatória , Infecções Respiratórias/complicaçõesRESUMO
Cockroach allergy was investigated in a group of 56 patients with atopic bronchial asthma (37 men and 19 women with ages ranging from 16 to 65) all allergic to house dust antigen. In all patients, both intracutaneous tests and bronchial provocation tests were performed with cockroach antigen prepared from the species most common in Poland, Blattella germanica and Blatta orientalis. Positive skin reactions to cockroach antigen were found in 17 patients while an immediate bronchoconstrictive response was noted in 11. In the authors opinion, cockroach antigens may be partly responsible for the antigenic properties of house dust and may play a causative role in some cases of atopic asthma.
Assuntos
Alérgenos/imunologia , Asma/etiologia , Baratas/imunologia , Adolescente , Adulto , Idoso , Alérgenos/isolamento & purificação , Asma/imunologia , Testes de Provocação Brônquica , Poeira , Feminino , Volume Expiratório Forçado , Humanos , Testes Intradérmicos , Masculino , Pessoa de Meia-IdadeRESUMO
A group of 145 patients with severe intrinsic bronchial asthma symptoms was treated with repeated intramuscular injections of triamcinolone acetonide (Kenalog) during an average period of two years. Kenalog was administered mainly to persons with persistent attacks of asthmatic dyspnea and frequent recurrent infections of the respiratory tract in which other drugs, including orally administered steroids, did not lead to any improvement in the asthmatic symptoms. The results of therapy were excellent (total disappearance of asthmatic manifestations) or good (considerable improvement of asthma symptoms) in 88.3% of treated cases, while in 11.7% of patients, Kenalog had no effect. In 13.8% of cases, side effects, especially weight gain, disturbances in menstruation, increase in blood pressure, edema and spontaneous echymoses were observed. The triamcinolone acetonide depot-preparation is, in the authors' opinion, highly effective in the management of severe intrinsic asthma cases, unsucessfully treated by other methods. The prolonged use of Kenalog can, however, like other steroids provoke, several side effects.
