RESUMO
BACKGROUND: Intensive lifestyle intervention trials in type 2 diabetes contribute evidence on what can be achieved under optimal conditions, but are less informative for translation in applied settings. PURPOSE: Living Well with Diabetes is a telephone-delivered weight loss intervention designed for real-world delivery. METHODS: This study is a randomized controlled trial of telephone counseling (n = 151) versus usual care (n = 151); 6-month primary outcomes of weight, physical activity, HbA1c; secondary diet outcomes; analysis was by adjusted generalized linear models. RESULTS: Relative to usual care, telephone counseling participants had small but significantly better weight loss [-1.12 % of initial body weight; 95 % confidence interval (CI) -1.92, -0.33 %]; physical activity [relative rate (RR) = 1.30; 95 % CI, 1.08, 1.57]; energy intake reduction (-0.63 MJ/day; 95 % CI, -1.01, -0.25); and diet quality (3.72 points; 95 % CI, 1.77, 5.68), with no intervention effect for HbA1c (RR = 0.99; 95 % CI, 0.96, 1.01). CONCLUSIONS: Results are discussed in light of challenges to intervention delivery.
Assuntos
Glicemia/metabolismo , Diabetes Mellitus Tipo 2/terapia , Atividade Motora , Educação de Pacientes como Assunto/métodos , Telefone , Programas de Redução de Peso/métodos , Adulto , Idoso , Diabetes Mellitus Tipo 2/metabolismo , Comportamento Alimentar/psicologia , Feminino , Hemoglobinas Glicadas/metabolismo , Índice Glicêmico , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do TratamentoRESUMO
The polysaccharides of the seeds of four species of agricultural lupin have been shown to comprise galactans, arabinogalactans, arabinans, rhamnogalacturonans, and galactoxyloglucans. Low molecular weight compounds were present in the mixtures after methylation of the acidic polysaccharides. Three tri-O-acetyl-O-methylhexuronic acids, with one hydroxyl group unsubstituted, formed during methylation, hydrolysis, and acetylation of the acidic polysaccharides, were present in high and variable proportions.