RESUMO
Eighteen patients with periodontal disease and measurable pockets were treated on a double-blind basis with coenzyme Q10 and a maching placebo. The treatment was significant (p less than 0.01). Before decoding, all 8 patients receiving coenzyme Q10 and 7/10 patients receiving placebo were correctly assigned. Of the remaining 3 placebo patients, the status of one was borderline and could have been assigned to either group, and two improved due to better hygiene. Crevicular fluid flow as a measure of inflammation was newly monitored. Pocket-depth, periodontal health, calculus and plaque scores provided the most valuable data for evaluation.
Assuntos
Doenças Periodontais/tratamento farmacológico , Ubiquinona/uso terapêutico , Ensaios Clínicos como Assunto , Gengiva/patologia , Humanos , Doenças Periodontais/patologia , Placebos , Fatores de Tempo , Ubiquinona/efeitos adversosRESUMO
Eight patients under routine care for periodontitis received oral treatment with a form of coenzyme Q (7 / CoQ10 and 1 / hexahydrocoenzyme Q4). An unchanged plaque score showed the patients cooperated and were under plaque control. The periodontal score decreased (p less than 0.01) on CoQ treatment. Unexpectedly, the periodontal pocket depth decreased (P less than 0.05) on CoQ treatment since all patients were considered candidates for surgical intervention. Healing was so excellent 5-7 days post-biopsy that the biopsy sites were difficult to locate. The healing was viewed as extraordinarily effective. The mean value of the specific activities of the succinate dehydrogenase-coenzyme Q10 reductase of gingival biopsies increased (P less than 0.05) during treatment which could correlate with the extraordinarily healing. Treatment of periodontitis with coenzyme Q should be considered as adjunctive treatment with current dental practice.
Assuntos
Periodontite/tratamento farmacológico , Ubiquinona/uso terapêutico , Adulto , Ensaios Clínicos como Assunto , Cálculos Dentários/tratamento farmacológico , Placa Dentária/tratamento farmacológico , Dieta , Eritrócitos/enzimologia , Gengiva/enzimologia , Gengiva/patologia , Humanos , Pessoa de Meia-Idade , Mitocôndrias/enzimologia , Oxirredutases/metabolismo , Índice Periodontal , Periodontite/enzimologia , Periodontite/patologia , Succinato Desidrogenase/metabolismoRESUMO
1. The grafted material appears extremely compatible with the animals tested for the observed time periods. 2. The procedures used led to the obliteration of surgically created one-wall infrabony periodontal pockets with fibrous connective tissue and/or bone. 3. The ready access, ease of placement and flexibility of the woven ceramic materials appear to provide some definite advantages over autogenous bone and many of the alloplastic materials presently being used in the correction of infrabony periodontal pockets. 4. Although in the experimental animals the graft materials appeared to be nontoxic, nonantigenic and compatible with the growth of new bone, long-term studies are indicated to determine is compatibility and potential to obliterate "chronic" periodontal lesions.
Assuntos
Cerâmica , Bolsa Gengival/cirurgia , Periodontite/cirurgia , Telas Cirúrgicas , Processo Alveolar/anatomia & histologia , Processo Alveolar/cirurgia , Animais , Materiais Biocompatíveis , Cães , Haplorrinos , Macaca mulatta , Osteoblastos/citologia , Ítrio , ZircônioRESUMO
The specific activities of both the succinate dehydrogenase-coenzyme Q(10) reductase and the DPNH-cytochrome c reductase [NADH:(acceptor)oxidoreductase, EC 1.6.99.3] were determined in mitochondria from 40 diseased gingival biopsies from patients with periodontal disease and from 24 control biopsies from nondiseased areas (clinically evaluated) of gingival tissues from the same mouths of the patients from whom the diseased gingival tissues were taken. The control tissue was taken during normal surgical procedures, such as for gingival recontouring and tuberosity removal. The diseased gingival biopsies showed a mean specific activity for the succinate dehydrogenase-coenzyme Q(10) reductase which was higher (P < 0.02) than that of the control biopsies, and which increased (P < 0.01) when the assays utilized exogenous coenzyme Q(3), and corresponded to an average deficiency of coenzyme Q(10)-enzyme activity of 35%. About 60% of the 40 diseased gingival tissues showed a deficiency of coenzyme Q(10) at its site in this succinate-coenzyme Q(10) enzyme. Of the 24 control tissues, 20% showed deficiencies of coenzyme Q(10). As a group, the control tissues showed no deficiency of coenzyme Q(10). No deficiency of coenzyme Q(10) at its site in DPNH-cytochrome c reductase was observed for either the control or diseased gingival tissues, as groups or individually.
