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1.
Clin Pediatr (Phila) ; 59(6): 566-572, 2020 06.
Artigo em Inglês | MEDLINE | ID: mdl-32146831

RESUMO

In 2018, the American Academy of Pediatrics warned consumers over the increasing use of imported infant formulas. The purpose of this study was to assess the usage of imported European infant formula among parents in a large urban private practice. An anonymous survey was distributed at well-child appointments to a convenience sample of parents at an urban private pediatric practice from November 2017 to March 2018. Of the 750 eligible respondents, 552 (74%) completed the survey. Of the parents using formula, 20% were using imported European infant formulas. The most commonly used formula was Holle (33%), and 72% were acquired from web-based third-party vendors. Parents chose to use these formulas because they believed that European formulas contained better ingredients. Only 8% of parents received information about European infant formula from their pediatricians. Pediatricians need to be aware of these formulas and their risks to educate families on the use and safety of these formulas.


Assuntos
Fórmulas Infantis/estatística & dados numéricos , Pais , Prática Privada , United States Food and Drug Administration , Estudos Transversais , Europa (Continente) , Humanos , Lactente , Cidade de Nova Iorque , Pediatria , Inquéritos e Questionários , Estados Unidos , População Urbana
2.
J Neurosci ; 29(25): 8215-24, 2009 Jun 24.
Artigo em Inglês | MEDLINE | ID: mdl-19553461

RESUMO

Neural phase signaling has gained attention as a putative coding mechanism through which the brain binds the activity of neurons across distributed brain areas to generate thoughts, percepts, and behaviors. Neural phase signaling has been shown to play a role in various cognitive processes, and it has been suggested that altered phase signaling may play a role in mediating the cognitive deficits observed across neuropsychiatric illness. Here, we investigated neural phase signaling in two mouse models of cognitive dysfunction: mice with genetically induced hyperdopaminergia [dopamine transporter knock-out (DAT-KO) mice] and mice with genetically induced NMDA receptor hypofunction [NMDA receptor subunit-1 knockdown (NR1-KD) mice]. Cognitive function in these mice was assessed using a radial-arm maze task, and local field potentials were recorded from dorsal hippocampus and prefrontal cortex as DAT-KO mice, NR1-KD mice, and their littermate controls engaged in behavioral exploration. Our results demonstrate that both DAT-KO and NR1-KD mice display deficits in spatial cognitive performance. Moreover, we show that persistent hyperdopaminergia alters interstructural phase signaling, whereas NMDA receptor hypofunction alters interstructural and intrastructural phase signaling. These results demonstrate that dopamine and NMDA receptor dependent glutamate signaling play a critical role in coordinating neural phase signaling, and encourage further studies to investigate the role that deficits in phase signaling play in mediating cognitive dysfunction.


Assuntos
Cognição , Proteínas da Membrana Plasmática de Transporte de Dopamina/deficiência , Dopamina/metabolismo , Hipocampo/fisiopatologia , Memória , Neurônios/metabolismo , Córtex Pré-Frontal/fisiopatologia , Receptores de N-Metil-D-Aspartato/deficiência , Transdução de Sinais , Animais , Proteínas da Membrana Plasmática de Transporte de Dopamina/genética , Eletrofisiologia , Potenciais Evocados , Comportamento Exploratório , Hipocampo/metabolismo , Aprendizagem em Labirinto , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Knockout , Camundongos Transgênicos , Vias Neurais/fisiopatologia , Córtex Pré-Frontal/metabolismo , Receptores de N-Metil-D-Aspartato/genética , Voo Espacial
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