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1.
Am J Trop Med Hyg ; 101(4): 753-760, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-31392956

RESUMO

The "Top End" of Australia is presently experiencing a gonorrhea epidemic. Gonococcal infection is usually limited to mucosal tissues but can lead to disseminated gonococcal infection (DGI), joint destruction, and severe sepsis. This study aimed to explore the epidemiology, presentation, management, and health-care impact of DGI in the Top End of the Northern Territory. Health records of patients diagnosed with proven, probable, or possible DGI between January 2010 and September 2018 were analyzed retrospectively. One hundred six cases of DGI were identified. Ninety-four patients (88.7%) were Indigenous Australian. The incidence of proven and probable DGI in the Indigenous population was 27.1 per 100,000 person-years, compared with 7.1 in the Top End population overall. Of 7,540 laboratory-proven gonococcal notifications, 1.3% (n = 97) were complicated by DGI. The highest incidence was in the 15-19-year age-group. Thirteen cases (12.3%) occurred in patients younger than 15 years. High rates of comorbid alcohol misuse, diabetes, systemic lupus erythematosus, rheumatic fever, and complement deficiency were observed. The "classic triad" of tenosynovitis, dermatitis, and polyarthralgia was rare. Ninety-four patients (88.7%) presented with purulent arthritis. Disseminated gonococcal infection was estimated to cause at least 10.0% of nonpenetrating septic arthritis in the Top End and 1,234 days of hospitalization during the study period. DGI is an important cause of morbidity in the Top End, particularly in the young, remote Indigenous Australian population. Clinical presentation varies from classical teaching. Urgent action in the health and community sector is required, particularly for at-risk populations, to prevent further debilitating and costly complications of gonococcal infection.


Assuntos
Artrite Infecciosa/epidemiologia , Gonorreia/epidemiologia , Neisseria gonorrhoeae/fisiologia , Sepse/epidemiologia , Adolescente , Adulto , Idoso , Artrite Infecciosa/microbiologia , Criança , Pré-Escolar , Feminino , Gonorreia/microbiologia , Humanos , Masculino , Pessoa de Meia-Idade , Northern Territory/epidemiologia , Estudos Retrospectivos , Sepse/microbiologia , Adulto Jovem
2.
J Infect ; 71(6): 642-8, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26416474

RESUMO

OBJECTIVES: To determine the prevalence of Salmonella in the environment of case and control houses, and compare serovars isolated from cases and their houses. METHODS: From 2005 to 2008, we tested samples from houses of 0-4 year old cases and community controls in Darwin and Palmerston for Salmonella. Case isolates were compared with environmental isolates. S. Ball and S. Urbana isolates were compared using Multiple Amplification of Phage Locus Typing (MAPLT) and Multiple-Locus Variable number of tandem repeat Analysis (MLVA). RESULTS: Salmonella were found in 47/65 (72%) case houses and 18/29 (62%) control houses; these proportions were not significantly different. In 21/47 (45%) houses, case and environmental isolates (from animal faeces, soil and vacuums) were indistinguishable. Multiple serovars were isolated from 20 (31%) case and 6 (21%) control houses. All but one environmental isolate are known human pathogens in the Northern Territory (NT). Each of the four pairs of S. Ball and S. Urbana were indistinguishable. CONCLUSIONS: Animal faeces were the most likely source of salmonellosis in cases. The similar prevalence of house isolates suggests that Salmonella is ubiquitous in this environment. The distinction of S. Ball and S. Urbana subtypes enabled linkage of human illness to environmental exposure. Environmental contamination with Salmonella is an important source of sporadic infection in children in the tropics.


Assuntos
Infecções por Salmonella/epidemiologia , Salmonella/isolamento & purificação , Microbiologia do Solo , Clima Tropical , Animais , Austrália/epidemiologia , Técnicas de Tipagem Bacteriana , Tipagem de Bacteriófagos , Estudos de Casos e Controles , Criança , Eletroforese em Gel de Campo Pulsado , Características da Família , Fezes/microbiologia , Humanos , Prevalência , Salmonella/genética , Salmonella/imunologia , Infecções por Salmonella/microbiologia , Sorogrupo
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