1.
J Org Chem
; 82(5): 2558-2569, 2017 03 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28169539
RESUMO
A mild method for the synthesis of 2-quinolinones via hydroarylation of N-aryl alkynamides is reported. While traditional methods have relied on the use of strong Brønsted or Lewis acids, this report describes the development of mild reaction conditions that yield 2-quinolinones in good to excellent yield using a commercially available gold catalyst. Substrates bearing a variety of functional groups are presented, with N-substitution proving to be key to the reactivity of several substrates.