RESUMO
The isolation and characterization of the title antibiotics, which are produced by the same Streptomyces sp., is described. The potent antitumor agent, PD 124,895, is an analog of hydroxyelactocin (PD 114,721). PD 124,966 is a new member of the depsipeptide family of antibiotics.
Assuntos
Antibióticos Antineoplásicos/isolamento & purificação , Peptídeos Cíclicos , Animais , Antibióticos Antineoplásicos/farmacologia , Fenômenos Químicos , Química , Ácidos Graxos Insaturados/isolamento & purificação , Ácidos Graxos Insaturados/farmacologia , Espectroscopia de Ressonância Magnética , Camundongos , Peptídeos/isolamento & purificação , Peptídeos/farmacologia , Streptomyces/metabolismoRESUMO
The isolation of two new antibiotics, PD 114,759 and PD 115,028, exhibiting in vivo antitumor activity at extremely low doses is described. The physico-chemical properties of these sulfur-containing compounds show that they represent a novel class of antitumor agents.
Assuntos
Antibióticos Antineoplásicos/isolamento & purificação , Produtos Biológicos , Actinomycetales/metabolismo , FermentaçãoRESUMO
A complex of structurally related compounds that exhibit in vivo antileukemic activity was isolated from fermentation broths of a new streptomycete. The components of this complex are water soluble phosphate esters containing a conjugated triene system. The isolation and characterization of three of these components are described.
Assuntos
Antibióticos Antineoplásicos/isolamento & purificação , Alcenos/isolamento & purificação , Cromatografia Líquida de Alta Pressão , Fermentação , Espectroscopia de Ressonância Magnética , Polienos , Pironas , Espectrofotometria , Streptomyces/crescimento & desenvolvimento , Relação Estrutura-AtividadeRESUMO
Butirosin, a new water-soluble aminoglycosidic antibiotic complex, active against gram-positive and gram-negative bacteria, has been isolated from fermentation filtrates of Bacillus circulans by ion exchange. The complex has been resolved into isomeric A and B components, C(21)H(41)N(5)O(12), by means of Dowex 1 x 1 or Dowex 1 x 2 chromatography. Properties of the free bases and the N, N', N'', N'''-tetraacetyl derivatives of butirosin A and B are given.
