RESUMO
A four-month-old female Dobermann presented with myalgia, dysphagia, progressive weakness and loss of body condition. Diagnostic evaluation at nine months of age revealed markedly elevated serum creatine kinase activity, electromyographic abnormalities and histological evidence of chronic-active muscle necrosis. Imaging confirmed dysphagia and aspiration pneumonia. Muscular dystrophy was suspected and immunohistochemical staining of muscle cryosections demonstrated reduced sarcoglycans. Treatment consisted of gastrostomy, and over the next 5 months the dog gained weight, despite continued loss of muscle mass. The dog died at 14 months of age after developing clinical signs of aspiration pneumonia. To the authors' knowledge, this is the first report of muscular dystrophy in a Dobermann and only the second detailed report of a canine sarcoglycanopathy. Supportive care resulted in an acceptable quality of life for 10 months after clinical signs were first observed.
Assuntos
Doenças do Cão/diagnóstico , Glicoproteínas de Membrana/deficiência , Distrofia Muscular Animal/diagnóstico , Animais , Diagnóstico Diferencial , Doenças do Cão/enzimologia , Doenças do Cão/patologia , Cães , Feminino , Glicoproteínas de Membrana/genética , Distrofia Muscular Animal/enzimologia , Distrofia Muscular Animal/patologiaAssuntos
Cromatografia Gasosa/métodos , Mexiletina/sangue , Propilaminas/sangue , Humanos , TemperaturaRESUMO
1. The metabolism of [14C]aniline in the cattle tick, Boophilus microplus (Canestrini) at 40 and 300 mug per animal) and in the spider, Nephila plumipes (at 40 mug per 100 mg) were studied. 2. In both species hydroxylation occurred yielding both free and conjugated o-and p-aminophenols. 3. The water-soluble metabolites affording aniline on acid hydrolysis were examined, and gamma-glutamylanilide (23% of dose) was identified as a tick metabolite (40 mug dose). This metabolite was not found in extracts of dosed spiders.
