1.
J Chem Inf Comput Sci
; 44(1): 221-9, 2004.
Artigo
em Inglês
| MEDLINE
| ID: mdl-14741031
RESUMO
A set of compounds consisting of a new and diverse collection of biarylamides was examined using quantitative structure-activity relationship techniques for the purpose of developing a model to describe inhibition of gram-positive bacterial growth (minimum inhibition concentration). The model was sought in order to obtain insight for designing new molecules. A detailed analysis of the underlying structure-activity relationship helped provide insight concerning which structural features of the molecules modulated the activity of the compounds against gram-positive organisms.