RESUMO
Five C(16)-alkynic fatty acids (2-6) were prepared and examined their inhibitory effects on cancer cell invasion. It has been found that hexadeca-6,8,10-triynoic acid (5) and hexadeca-8,10,12-triynoic acid (6) exhibit similar potent inhibitory activities with that of octadeca-8,10,12-triynoic acid (1) which was isolated from Scurrula atropurpurea (Loranthaceae).
Assuntos
Alcinos/farmacologia , Antineoplásicos/farmacologia , Ácidos Graxos/farmacologia , Inibidores do Crescimento/farmacologia , Alcinos/química , Animais , Antineoplásicos/química , Ácidos Graxos/química , Inibidores do Crescimento/química , Loranthaceae , Extratos Vegetais/química , Extratos Vegetais/farmacologia , Ratos , Células Tumorais CultivadasRESUMO
Six fatty acids (1-6), two xanthines (7, 8), two flavonol glycosides (9, 10), one monoterpene glucoside (11), one lignan glycoside (12), and four flavanes (13-16) were clarified by a bioassay-guided separation as chemical constituents of Scurrula atropurpurea (Loranthaceae), a parasitic plant of the tea plant Thea sinensis (Theaceae). Among these constituents, it was found that the alkynic fatty acid octadeca-8,10,12-triynoic acid (6) exhibits a more potent inhibitory effect on cancer cell invasion in vitro than flavanes [(+)-catechin (13), (-)-epicatechin (14), (-)-epicatechin-3-O-gallate (15) and (-)-epigallocatechin-3-O-gallate (16)].
Assuntos
Loranthaceae , Extratos Vegetais/química , Extratos Vegetais/farmacologia , Animais , Camellia sinensis , Avaliação Pré-Clínica de Medicamentos/métodos , Indonésia , Extratos Vegetais/isolamento & purificação , Folhas de Planta , Caules de Planta , Plantas Medicinais , Ratos , Células Tumorais Cultivadas/efeitos dos fármacosRESUMO
The microbial transformation of four Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine) by endophytic fungi isolated from Cinchona pubescens was investigated. The endophytic filamentous fungus Xylaria sp. was found to transform the Cinchona alkaloids into their 1-N-oxide derivatives.
Assuntos
Alcaloides de Cinchona/química , Cinchona/microbiologia , Fungos , Óxidos/química , Biotransformação , Cinchona/química , Fungos/química , Fungos/isolamento & purificação , Caules de Planta/química , Caules de Planta/microbiologiaRESUMO
A complex of perseitol (D-glycero-D-galacto-heptitol) and K+ ions in a molar ratio of 20:1 was isolated from the leaves of Scurrula fusca (Loranthaceae), which has been traditionally used for the treatment of cancer in Sulawesi Island, Indonesia. The stereochemical structure of the complex in H2O solution has been elucidated by use of several kinds of NMR techniques. Furthermore, it has been found that the complex exhibits a potent inhibitory effect on [3H]-leucine incorporation for protein synthesis in Ehrlich ascites tumor cells in mice.
