Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
eNeuro ; 10(5)2023 05.
Artigo em Inglês | MEDLINE | ID: mdl-37164637

Assuntos
Glaucoma , Humanos , Sinapses
2.
Nat Commun ; 13(1): 6194, 2022 10 19.
Artigo em Inglês | MEDLINE | ID: mdl-36261441

RESUMO

Postnatal neurogenesis provides an opportunity to understand how newborn neurons integrate into circuits to restore function. Newborn olfactory sensory neurons (OSNs) wire into highly organized olfactory bulb (OB) circuits throughout life, enabling lifelong plasticity and regeneration. Immature OSNs form functional synapses capable of evoking firing in OB projection neurons but what contribution, if any, they make to odor processing is unknown. Here, we show that immature OSNs provide odor input to the mouse OB, where they form monosynaptic connections with excitatory neurons. Importantly, immature OSNs respond as selectively to odorants as mature OSNs and exhibit graded responses across a wider range of odorant concentrations than mature OSNs, suggesting that immature and mature OSNs provide distinct odor input streams. Furthermore, mice can successfully perform odor detection and discrimination tasks using sensory input from immature OSNs alone. Together, our findings suggest that immature OSNs play a previously unappreciated role in olfactory-guided behavior.


Assuntos
Neurônios Receptores Olfatórios , Camundongos , Animais , Neurônios Receptores Olfatórios/fisiologia , Bulbo Olfatório/fisiologia , Odorantes , Neurogênese/fisiologia , Interneurônios
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...