Does prayer influence the success of in vitro fertilization-embryo transfer? Report of a masked, randomized trial.

OBJECTIVE: To assess the potential effect of intercessory prayer (IP) on pregnancy rates in women being treated with in vitro fertilization-embryo transfer (IVF-ET). STUDY DESIGN: Prospective, double-blind, randomized clinical trial in which patients and providers were not informed about the intervention. Statisticians and investigators were masked until all the data had been collected and clinical outcomes were known. The setting was an IVF-ET program at Cha Hospital, Seoul, Korea. IP was carried out by prayer groups in the United States, Canada and Australia. The investigators were at a tertiary medical center in the United States. The patients were 219 women aged 26-46 years who were consecutively treated with IVF-ET over a four-month period. Randomization was performed after stratification of variables in two groups: distant IP vs. no IP. The clinical pregnancy rates in the two groups were the main outcome measure. RESULTS: After clinical pregnancies were known, the data were unmasked to assess the effects of IP after assessment of multiple comparisons in a log-linear model. The IP group had a higher pregnancy rate as compared to the no-IP rate (50% vs. 26%, P = .0013). The IP group showed a higher implantation rate (16.3% vs. 8%, P = .0005). Observed effects were independent of clinical or laboratory providers and clinical variables. CONCLUSION: A statistically significant difference was observed for the effect of IP on the outcome of IVF-ET, though the data should be interpreted as preliminary.

Multisite electromyographic analysis of therapeutic touch and qigong therapy.

The influence of complementary healing treatment on paraspinal electromagnetic activity at specific neuromuscular sites was examined in an exploratory pilot study that used a multisite surface electromyographic (sEMG) assessment procedure. The study was a replication and extension of previous research that indicated that complementary healing had a significant effect in normalizing the activity of the "end organ" for the central nervous system (CNS). Multisite sEMG electrodes were placed on the frontalis, cervical (C4), thoracic (T6), and lumbosacral (L3) paraspinals of 44 subjects who were divided into three groups: (1) students/patients of a Qigong practitioner (n = 16); (2) students/patients of a therapeutic touch (TT) practitioner (n = 14); and (3) nonbelievers in complementary healing (n = 14). A traditional ABAC experimental design was used with each subject evaluated for one 20-minute session that included four 5-minute segments. The purpose of this study was to measure the variable energizing effect of Qigong therapy along with the anecdotally and experimentally established relaxation effect of TT therapy relative to patient belief and expectancy. Treatment sessions consisted of Qigong and a modified form of TT intervention for all three groups. Due to the double-blind nature of the study, however, group 1 subjects were aware of only the Qigong intervention; group 2 subjects were aware of only the TT intervention, and group 3 subjects were informed that the study was designed to assess the neuromuscular activity of individuals in a seated position. The results indicated a statistically significant rise in electromagnetic activity for group 1 during the Qigong intervention segment (p < .024). Group 2 demonstrated a modest although overall nonsignificant decrease in multisite sEMG levels for both treatment protocols, whereas group 3 exhibited relatively consistent neuromuscular activity for both control and treatment segments. The results of this study are considered preliminary in nature, however, due to the potential influence of several confounds including psychophysiological factors, established behavior patterns, and the possibility for information transfer due to sensory cues.

Multisite surface electromyography and complementary healing intervention: a comparative analysis.

A comparative analysis was conducted on a series of three experimental studies that examined the effect of various local and nonlocal (distant) complementary healing methods on multisite surface electromyographic (sEMG) and autonomic measures. The series concentrated sEMG electrode placement on specific neuromuscular paraspinal centers (cervical [C4], thoracic [T6], and lumbar [L3]), along with the frontalis region, due to the fact that these sites corresponded to the location of individual chakra centers as delineated in ancient Eastern medical and philosophical texts. It was hypothesized that the sEMG assessment procedure had the potential to provide objective, quantifiable correlates for complementary healing treatment effects, as well as assess the energy flow through the chakras during a healing treatment. The studies were the first of their kind to incorporate randomized, double-blind, placebo-controlled protocols in order to evaluate correlative neuromuscular multisite sEMG paraspinal measures with different complementary healing treatment interventions. Although the measurement protocols were similar between experiments, the results, demonstrated by the individual studies, varied. Whereas the overall findings of the series are encouraging because they indicate a potential objective scientific correlate to complementary healing treatment intervention, the results are considered preliminary in nature and appear to be linked to either the meditational experience of the subjects or dependent on the particular healer(s) used. Additional research is needed in order to establish the multisite sEMG assessment procedure as a reliable correlative measure for complementary healing treatment effects and to determine whether a consistent replicative treatment effect can be demonstrated independent of the specific subject population or practitioner(s) used.

Wound healing and complementary therapies: a review.

A series of five innovative experiments conducted by Wirth et al. which examined the effect of various complementary healing interventions on the reepithelialization rate of full thickness human dermal wounds was assessed as to specific methodological and related factors. The treatment interventions utilized in the series included experimental derivatives of the Therapeutic Touch (TT), Reiki, LeShan, and Intercessory Prayer techniques. The results of the series indicated statistical significance for the initial two experiments and nonsignificance or reverse significance for the remaining three studies. This review article examines the methodological designs of the series of studies, along with the TT practitioners' phenomenologically based journal reports, to provide potential contributing correlative factors for the differential results obtained. These factors include: (1) methodological design restrictions, (2) a transference/inhibitory effect (3) the influence of experimental assistants, (4) healer visualization /imagery techniques, (5) variations in subject populations, and (6) a potential cancellation effect. While the placebo controlled double-blind methodological designs used in the series were as stringent as those used in other fields of scientific inquiry, the overall results of the experiments were inconclusive in establishing the efficacy of the treatment interventions for accelerating the rate of reepithelialization of full thickness dermal wounds.

The significance of belief and expectancy within the spiritual healing encounter.

Historically, traditional cultures recognized the importance of belief and expectancy within the healing encounter and created complex rituals and ceremonies designed to elicit or foster the expectancy and participation of both the healer and patient, as well as the community as a whole. This holistic approach to health care was a fundamental component in the spiritual healing rituals of virtually all traditional native cultures. The focus of the current study was to assess the impact of healer and patient expectations on mental and physical health parameters following a spiritual healing session. A pre-post methodological design which incorporated extensive psychophysiological health outcome measures along with independent medical diagnoses was utilized. The study was conducted in a northern California suburb of Marin County utilizing an American-born spiritual healer trained in the Philippines. The results indicated that there was a statistically significant difference between the pre-treatment and post-treatment scores for all fourteen dependent variables examined. The data also demonstrated a significant difference between the high versus low expectancy subjects for both patient and healer groups, as well as a significant relationship between high expectancy in patients and healer and the effectiveness of the spiritual healing encounter. The results of the study therefore suggest that high healer and patient expectancy may be important elements which can serve as both predictors as well as facilitators of the healing process. The degree of bonding or communication between the healer and patient was postulated as an important factor in this regard. Due to the fact that a majority of the conditions reported (75%) were organic disorders that would not commonly disappear within the 3 week time frame of the study, the significant results obtained suggest that spiritual healing in combination with traditional allopathic medicine may have the potential to be an effective treatment protocol for severe or long-term disorders. An important contributing feature of this study was that an independent means of assessing the patients' self-reports, i.e. an allopathic medical examination, was included in the experiment. There was a significant correlation between the patient's expectation level and their assessment of improvement, as well as a significant relationship between the patient's assessment of their condition and the objective evaluations provided by independent medical examinations.

Complementary healing intervention and dermal wound reepithelialization: an overview.

A comparative analysis was conducted on a series of five experiments which examined the effect of complementary healing to the reepithelialization rate of full thickness human dermal wounds. The treatment intervention focused primarily on Noncontact Therapeutic Touch, which was administered within randomized, double-blind, placebo-controlled experimental protocols. An important methodological component of the studies was that in general the complementary healing practitioners were separated or isolated from the participants and subjects. This design element, coupled with the fact that in four of the five experiments subjects were blinded to the nature of the active treatment modality, resulted in the preclusion of suggestion, expectation, and the placebo effect; the factors which have confounded most prior complementary healing research. The results of the experiments indicated significance for the treatment group in the initial two studies in the series, and nonsignificant and reverse significant results for the control group in the remaining three experiments. Several factors were postulated as important considerations in the differential results obtained including: (1) cancellation and inhibitory elements; (2) carryover and learning effects; and (3) potential experimenter and placebo effect factors. Although the five studies represent a seminal research effort within the field of complementary healing, the overall results of the series are inconclusive in establishing the efficacy of the treatment interventions examined.

Complementary healing therapies.

The effect of non-contact therapeutic touch (NCTT) in isolation and in combination with Reiki, LeShan, and Intercessory Prayer on the healing rate of full thickness human dermal wounds was examined utilizing a randomized, double-blind, within subject, crossover design. The protocol incorporated an integral biofeedback, guided imagery, and visualization/relaxation component in order to assess the influence of psychophysiological factors on the healing process. Biopsies were performed on the lateral deltoid in healthy subjects and assessed by two independent physicians for the rate of reepithelialization at day 5 and day 10. Subjects met as a group on odd numbered days for a one hour visualization/relaxation session which incorporated guided imagery with either a specific intent to heal their biopsy wound or a specific intent to relax. Treatment intervention included two NCTT healers or two mimic practitioners who worked in-person for a duration of 6 minutes per subject. LeShan and Intercessory Prayer healers worked at a distance and a Reiki healer worked in-person with the NCTT healers. On even numbered days, subjects were trained in hand temperature biofeedback with either a specific intent to heal or a specific intent to relax. Results showed significance for the treated versus the control group but in the opposite direction from that expected. Several factors could have contributed to the nonsignificance obtained including: (a) the natural healing ability of the two mimic practitioners; (b) the subjects' increased proficiency with the self-regulatory techniques; and (c) a carryover effect from the two NCTT healers and/or the Reiki, LeShan, or Intercessory Prayer healers.

The psychophysiology of nontraditional prayer.

This study was a replication and extension of previous research which indicated that Non-Contact Therapeutic Touch had a significant effect in normalizing the activity of the "end organ" for the central nervous system (CNS). The study utilized a randomized double-blind within subject crossover methodological design to examine the effect of nontraditional distant prayer upon autonomic and CNS parameters. The impact of complementary healing was assessed utilizing multi-site surface electromyographic (sEMG) recordings located at the frontalis, Cervical 4 paraspinals, Thoracic 6 paraspinals, and Lumbosacral 3 paraspinals. The autonomic indicators of physiological activity included hand temperature, heart rate, skin conductance levels (SCL), and blood volume pulse (BVP). Twenty-one subjects were randomly assigned to treatment and control conditions for two thirty minute evaluation sessions for a total of forty-two psychophysiological monitoring periods. All participants were blinded to the true nature of the experimental protocol as well as the fact that a healing study was being conducted in order to control for suggestion, expectation of healing, and the placebo effect. The analysis of autonomic indicators demonstrated a slight decrease in BVP and heart rate, coupled with a minor increase in SCL suggesting a mild "anticipatory effect" arousal trend. The data also showed that two of the four muscle regions monitored-T6 and L3 paraspinals-indicated a significant reduction in electromagnetic energy during and following the distant healing treatment intervention for a majority of the subjects. For example, the T6 SEMG showed significance at the p < .0002 level, while the L3 SEMG indicated significance at the p < .001 level.(ABSTRACT TRUNCATED AT 250 WORDS)

Multi-site electromyographic analysis of non-contact therapeutic touch.

Therapeutic Touch (TT) has been an active change agent within the field of medicine since its introduction as a nursing intervention in 1975. A critical factor which has been missing from the research conducted in this area, however, is definitive scientific evidence or documentation that TT has an objective quantifiable impact upon the physiology of the subject. This study utilized a randomized ABAC methodological design to investigate the effect of TT without contact (NCTT) upon autonomic and CNS parameters. The subjects were blinded to the true nature of the experimental protocol as well as the fact that a healing study was being conducted in order to control for placebo and expectation effects. The impact of NCTT was assessed by multi-site surface EMG recordings located at the Frontalis, Cervical 4 paraspinals, Thoracic 6 paraspinals, and Lumbosacral 3 paraspinals. Autonomic indicators of physiological activity were also monitored and included hand and head temperature, heart rate, and end tidal CO2 levels. The results demonstrated that all of the autonomic indicators showed a general trend towards lower levels of arousal over time. The data also showed that three of the four muscle regions monitored--C4, T6, and L3 paraspinals--indicated a significant reduction in energy during and following the NCTT treatment sessions for a majority of the subjects. For example, the C4 EMG showed a significant NCTT treatment effect (F = 10.31; df = 1; p < .009 level), while the T6 EMG (F = 13.49; df = 1; p < .004) and L3 EMG (F = 4.74; df = 1; p < .05) also demonstrated significance. In addition to the habituation effects seen in the autonomic variables, the implications of neutralization of postural homeostasis and lowering of emotional arousal are discussed along with consideration of the Eastern concept of "nadis."