Trunk Skeletal Muscle Changes on CT with Long-Duration Spaceflight.

Astronauts exposed to microgravity for extended time are susceptible to trunk muscle atrophy, which may compromise strength and function on mission and after return. This study investigates changes in trunk skeletal muscle size and composition using computed tomography (CT) and dual-energy X-ray absorptiometry (DXA) among 16 crewmembers (1 female, 15 male) on 4-6 month missions. Muscle cross-sectional area and muscle attenuation were measured using abdominal CT scans at pre-flight, post-flight return, 1 year post-flight, and 2-4 years post-flight. Longitudinal muscle changes were analyzed using mixed models. In six crewmembers, CT and DXA data were used to calculate subject height-normalized skeletal muscle indices. Changes in these indices were analyzed using paired t-tests and compared by imaging modality using Pearson correlations. Trunk muscle area decreased at post-flight return (- 4.7 ± 1.1%, p < 0.001) and recovered to pre-flight values at 1-4 years post-flight. Muscle attenuation changes were not significant. Skeletal muscle index from CT decreased (- 5.2 ± 1.0%, p = 0.004) while appendicular skeletal muscle index from DXA did not change significantly. In summary, trunk muscle atrophies with long-duration microgravity exposure but recovers to pre-flight values within 1-4 years. The CT measures highlight size decreases not detected with DXA, emphasizing the importance of advanced imaging modalities in assessing muscle health with spaceflight.

Finite element reconstruction of a vehicle-to-pedestrian impact.

OBJECTIVE: This study aims to reconstruct a real-world Crash Injury Research and Engineering Network vehicle-to-pedestrian impact to supplement the determination of pedestrian kinematics and injury causation. METHODS: A case involving a 46-year-old male pedestrian with a height of 163 cm and mass of 100 kg that was impacted by a 2019 Dodge Charger Pursuit police cruiser at an approximate velocity of 20.1 m/s was reconstructed. The case vehicle was represented by a rigid shell of a 2019 Dodge Charger vehicle exterior from an open-source database. The case pedestrian was represented by the Global Human Body Models Consortium (GHBMC) 50th percentile male simplified pedestrian human body model. The GHBMC model was isometrically scaled to a height of 163 cm and the external layer of flesh was morphed to a male reference geometry with the same age, height, and body mass index as the case pedestrian. The approximate location and position of the pedestrian at the time of impact was determined from case vehicle dashboard camera images and the pedestrian model was adjusted accordingly. RESULTS: Reconstruction kinematics aligned with proposed CIREN case kinematics. The GHBMC model predicted fractures of the left inferior ischiopubic ramus, superior pubic ramus, ilium, sacral ala, acetabulum, and right ilium. CONCLUSIONS: Finite element reconstructions of real-world pedestrian impacts are useful for analyzing pedestrian kinematics and provide an effective tool for improving pedestrian impact injury analyses.