Mobilize Is a Verb: The Use of Verbs and Concrete Language Is Associated With Authors' and Readers' Perceptions of a Text's Action Orientation and Persuasiveness.

In three studies, we investigated the role of linguistic features characterizing texts aiming to mobilize others. In Study 1 (N = 728), participants produced a leaflet either mobilizing others to engage in an action or expressing their thoughts about that action, and evaluated how action-oriented their text was. Mobilizing texts included more verbs and concrete words, and the presence of these linguistic characteristics was positively linked to participants' evaluations of their messages as action-oriented. In Studies 2 and 3 (N = 557 and N = 556), independent groups of participants evaluated texts produced in Study 1. Readers' perceptions of texts as action-oriented were associated with the same linguistic features as in Study 1 and further positively linked to perceived message effectiveness (Study 2) and behavioral intention (Study 3). The studies reveal how encoding and decoding of verbs and concrete words serve as distinct persuasive tools in calls to action.

Oxidative Stress in Xenograft Mouse Model Exposed to Dendrimers Decorated Polydopamine Nanoparticles and Targeted Chemo- and Photothermal Therapy.

Polydopamine (PDA)-based nanostructures are used for biomedical purposes. A hybrid drug nanocarrier based on a PDA decorated with polyamidoamine (PAMAM) dendrimers G 3.0 (DG3) followed by a connection with glycol (PEG) moieties, folic acid (FA), and drug doxorubicin (DOX) was used for combined chemo- and photothermal therapy (CT-PTT) of liver cancer. Oxidative stress plays a crucial role in the development of cancer, and PDA seems to have the ability to both donate and accept electrons. We investigated oxidative stress in organs by evaluating oxidative stress markers in vivo. In the liver, the level of reduced glutathione (GSH) was lower and the level of Trolox equivalent antioxidant capacity (TEAC) was higher in the group receiving doxorubicin encapsulated in PDA nanoparticles with phototherapy (PDA@DG3@PEG@FA@DOX + PTT) compared to the control group. The concentration of thiobarbituric acid reactive substances (TBARS) in livers, was higher in the group receiving PDA coated with PAMAM dendrimers and functionalized with PEG and FA (PDA@DG3@PEG@FA) than in other groups. Markers in the brain also showed lower levels of GSH in the PDA@DG3@PEG@FA group than in the control group. Markers of oxidative stress indicated changes in the organs of animals receiving PDA nanoparticles with PAMAM dendrimers functionalized with FA in CT-PTT of liver cancer under in vivo conditions. Our work will provide insights into oxidative stress, which can be an indicator of the toxic potential of PDA nanoparticles and provide new strategies to improve existing therapies.

Factors affecting fledglings survival in urban population of European blackbirds in Szczecin (NW Poland).

The first-year survival alters population growth rates and viability in birds, however this period remains the least-studied of the avian life stages. Here we present results of the 19 years of study of fledglings apparent survival of urban population of European blackbird Turdus merula in Szczecin (NW Poland). We checked for possible influence on survival of several factors, including parental traits, such as parental age, their previous breeding experience, natal brood size, presence of another brood in a given breeding season and the time gap between clutches of a particular pair. Moreover, we incorporate into our analysis fledging's hierarchy in the brood, its fledging time in the breeding season, temperature and precipitation during the first months of life. We also investigated changes in the apparent survival over 19 years. We found that the individual's hierarchy in the nest, and the day of fledging had the strongest influence on the apparent survival, with heavier birds fledged earlier in the season surviving better. Increase in parental age and previous breeding experience of the pair could result in enhanced survival. Surprisingly increased precipitation lowered fledglings' survival. During the 19 years of the study fledglings' apparent survival dropped about 10%.

Polydopamine-Based Material and Their Potential in Head and Neck Cancer Therapy-Current State of Knowledge.

Head and neck cancers (HNC) are among the most common cancers in the world. In terms of frequency of occurrence in the world, HNC ranks sixth. However, the problem of modern oncology is the low specificity of the therapies used, which is why most of the currently used chemotherapeutic agents have a systemic effect. The use of nanomaterials could overcome the limitations of traditional therapies. Researchers are increasingly using polydopamine (PDA) in nanotherapeutic systems for HNC due to its unique properties. PDA has found applications in chemotherapy, photothermal therapy, targeted therapy, and combination therapies that facilitate better carrier control for the effective reduction of cancer cells than individual therapies. The purpose of this review was to present the current knowledge on the potential use of polydopamine in head and neck cancer research.

Oxidative Stress in Long-Term Exposure to Multi-Walled Carbon Nanotubes in Male Rats.

Multi-walled carbon nanotubes (MWCNTs) serve as nanoparticles due to their size, and for that reason, when in contact with the biological system, they can have toxic effects. One of the main mechanisms responsible for nanotoxicity is oxidative stress resulting from the production of intracellular reactive oxygen species (ROS). Therefore, oxidative stress biomarkers are important tools for assessing MWCNTs toxicity. The aim of this study was to evaluate the oxidative stress of multi-walled carbon nanotubes in male rats. Our animal model studies of MWCNTs (diameter ~15-30 nm, length ~15-20 µm) include measurement of oxidative stress parameters in the body fluid and tissues of animals after long-term exposure. Rattus Norvegicus/Wistar male rats were administrated a single injection to the knee joint at three concentrations: 0.03 mg/mL, 0.25 mg/mL, and 0.5 mg/mL. The rats were euthanized 12 and 18 months post-exposure by drawing blood from the heart, and their liver and kidney tissues were removed. To evaluate toxicity, the enzymatic activity of total protein (TP), reduced glutathione (GSH), glutathione S-transferase (GST), thiobarbituric acid reactive substances (TBARS), Trolox equivalent antioxidant capacity (TEAC), nitric oxide (NO), and catalase (CAT) was measured and histopathological examination was conducted. Results in rat livers showed that TEAC level was decreased in rats receiving nanotubes at higher concentrations. Results in kidneys report that the level of NO showed higher concentration after long exposure, and results in animal serums showed lower levels of GSH in rats exposed to nanotubes at higher concentrations. The 18-month exposure also resulted in a statistically significant increase in GST activity in the group of rats exposed to nanotubes at higher concentrations compared to animals receiving MWCNTs at lower concentrations and compared to the control group. Therefore, an analysis of oxidative stress parameters can be a key indicator of the toxic potential of multi-walled carbon nanotubes.

Gender bias in special issues: evidence from a bibliometric analysis.

Even though the majority of psychologists are women, they are outnumbered by men in senior academic ranks. One reason for this representation bias in academia is that men favor other men in decision-making, especially when the stakes are high. We tested the possibility of such bias in a bibliometric analysis, in which we coded editors' and authors' gender in regular and special issues, the latter considered of higher scientific prominence. We examined all special issues from five prominent scientific outlets in the fields of personality and social psychology published in the twenty-first century. Altogether, we analyzed 1911 articles nested in 93 sets comprising a special issue and a neighboring regular issue treated as a control condition. For articles published in special (but not regular) issues, when there were more men editors, more men first-authored and co-authored the work. This pattern suggests how gender bias can be perpetuated within academia and calls for revising the editorial policies of leading psychology journals.

Assessment of Pristine Carbon Nanotubes Toxicity in Rodent Models.

Carbon nanotubes are increasingly used in nanomedicine and material chemistry research, mostly because of their small size over a large surface area. Due to their properties, they are very attractive candidates for use in medicine and as drug carriers, contrast agents, biological platforms, and so forth. Carbon nanotubes (CNTs) may affect many organs, directly or indirectly, so there is a need for toxic effects evaluation. The main mechanisms of toxicity include oxidative stress, inflammation, the ability to damage DNA and cell membrane, as well as necrosis and apoptosis. The research concerning CNTs focuses on different animal models, functionalization, ways of administration, concentrations, times of exposure, and a variety of properties, which have a significant effect on toxicity. The impact of pristine CNTs on toxicity in rodent models is being increasingly studied. However, it is immensely difficult to compare obtained results since there are no standardized tests. This review summarizes the toxicity issues of pristine CNTs in rodent models, as they are often the preferred model for human disease studies, in different organ systems, while considering the various factors that affect them. Regardless, the results showed that the majority of toxicological studies using rodent models revealed some toxic effects. Even with different properties, carbon nanotubes were able to generate inflammation, fibrosis, or biochemical changes in different organs. The problem is that there are only a small amount of long-term toxicity studies, which makes it impossible to obtain a good understanding of later effects. This article will give a greater overview of the situation on toxicity in many organs. It will allow researchers to look at the toxicity of carbon nanotubes in a broader context and help to identify studies that are missing to properly assess toxicity.

Emotional framing in online environmental activism: Pairing a Twitter study with an offline experiment.

As the consequences of anthropogenic climate change become more apparent, social media has become a central tool for environmental activists to raise awareness and to mobilize society. In two studies, we examine how the emotional framing of messages posted by environmental activists influences engagement and behavioral intentions toward environmental action. In the first study, tweets (N = 510k) of 50 environmental activists posted between November 2015 and December 2020 are examined to measure their emotional content and its relation to tweet diffusion. Environment-related tweets are found to be shared more the less they contain positive emotion and the more they contain negative emotion. This result supports the negativity bias on social media. In Study 2 (N = 200), we experimentally test whether negatively vs. positively framed environmental content leads to increased reported intent to engage with collective action, and whether mood mediates that link. We find both direct and indirect effects on reported climate action intentions when mood is used as a mediator. The negative mood resulting from seeing negative tweets makes participants more likely to report higher action intention (indirect effect)-congruent with Study 1. However, seeing negative tweets also makes participants less inclined to act (direct effect), indicating a suppression effect and the presence of other factors at work on the pathway between information and action intent formation. This work highlights the complex and multifaceted nature of this relation and motivates more experimental work to identify other relevant factors, as well as how they relate to one another.

Aging and Hypertension - Independent or Intertwined White Matter Impairing Factors? Insights From the Quantitative Diffusion Tensor Imaging.

Aging disrupts white matter integrity, and so does continuous elevated blood pressure that accompanies hypertension (HTN). Yet, our understanding of the interrelationship between these factors is still limited. The study aimed at evaluating patterns of changes in diffusion parameters (as assessed by quantitative diffusion fiber tracking - qDTI) following both aging, and hypertension, as well as the nature of their linkage. 146 participants took part in the study: the control group (N = 61) and the patients with hypertension (N = 85), and were divided into three age subgroups (25-47, 48-56, 57-71 years). qDTI was used to calculate the values of fractional anisotropy, mean, radial and axial diffusivity in 20 main tracts of the brain. The effects of factors (aging and hypertension) on diffusion parameters of tracts were tested with a two-way ANOVA. In the right hemisphere there was no clear effect of the HTN, nor an interaction between the factors, though some age-related effects were observed. Contrary, in the left hemisphere both aging and hypertension contributed to the white matter decline, following a functional pattern. In the projection pathways and the fornix, HTN and aging played part independent of each other, whereas in association fibers and the corpus callosum if the hypertension effect was significant, an interaction was observed. HTN patients manifested faster decline of diffusion parameters but also reached a plateau earlier, with highest between-group differences noted in the middle-aged subgroup. Healthy and hypertensive participants have different brain aging patterns. The HTN is associated with acceleration of white matter integrity decline, observed mainly in association fibers of the left hemisphere.

Traumatic Rift: How Conspiracy Beliefs Undermine Cohesion After Societal Trauma?

Collective traumas may often lead to deep societal divides and internal conflicts. In this article, we propose that conspiracy theories emerging in response to victimizing events may play a key role in the breakdown of social cohesion. We performed a nationally representative survey in Poland (N = 965) two years after the Smolensk airplane crash in which the Polish president was killed, together with 95 political officials and high-ranking military officers. The survey found that people endorsing conspiratorial accounts of the Smolensk catastrophe preferred to distance themselves from conspiracy non-believers, while skeptics preferred greater distance to conspiracy believers. We also examined the role of people's belief in the uniqueness of in-group historical suffering as an important antecedent of both conspiracy thinking and hostility towards outgroups (conspiracy believers and non-believers).

Beneficial effect of ovocystatin on the cognitive decline in APP/PS1 transgenic mice.

PURPOSE: Cystatin C plays an important role in the course of neurodegenerative diseases and has a beneficial effect through inhibiting cysteine proteases and amyloid-ß aggregation. It also induces proliferation and autophagy. Cystatin isolated from chicken egg white, called ovocystatin, has been widely used in the medical and pharmaceutical research due to its structural and biological similarities to human cystatin C. The aim of this study was to assess the effect of administering ovocystatin on the development of dementia-specific cognitive deficits in APP/PS1 transgenic mice. MATERIALS/METHODS: The study was conducted on transgenic B6C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax mice. Ovocystatin was administered to four-month-old transgenic (AD) and wild type (NCAR) mice in drinking water for 24 weeks (at a dose of 40 and 4 µg/ mouse). The locomotor activity and cognitive functions were determined using an actimeter and the Morris water maze test, respectively. RESULTS: The results of the study indicate that ovocystatin has a beneficial effect on the cognitive functions in APP/PS1 transgenic mice. The strongest effects of ovocystatin were found in the group of AD mice, where ovocystatin was administered in drinking water at a dose of 40 µg/mouse (p < 0.05). Mice from the AD group swam statistically significantly further in the target zone during the trial in the Morris water maze compared to the AD (vehiculum) group (p < 0.05). CONCLUSIONS: The obtained results encourage further research into the protective effect, which may be used as an adjuvant in the treatment of deteriorating cognitive functions.

An animal model of the procognitive properties of cysteine protease inhibitor and immunomodulatory peptides based on colostrum.

BACKGROUND: The positive effect of human cystatin C on the development of Alzheimer's disease has been reported, as it inhibits the formation of ß-amyloid oligomers and amyloidogenesis. Cystatin C has been found to have a neuroprotective effect by inhibiting cysteine proteases, inducing autophagy and neurogenesis. There is a growing interest in the procognitive properties of colostrum-based specimens, which could delay dementia and ameliorate memory deterioration. OBJECTIVES: The aim of the study was to evaluate the influence of ovocystatin and a Coloco peptide complex on the cognitive functions in reference to Colostrinin, using a model of young (4 month-old) and old (10-month-old) Wistar rats. MATERIAL AND METHODS: In the present study, the effects of ovocystatin [100 µg/rat] and the Coloco peptide [4 µg/rat]derived from colostrum were assessed with respect to the reference specimen, Colostrinin [4 µg/rat]. The specimens were administered intraperitoneally and orally for 12 days. Cognitive functions were assessed using the Morris water maze (MWM). RESULTS: The group of young rats that received ovocystatin orally obtained significantly better results in the MWM compared to the placebo group (p < 0.05). Similarly, the group of young rats receiving Coloco orally obtained better results in the MWM compared to the placebo group and to the group of rats receiving Colostrinin (p < 0.05). There were no statistically significant differences in the oral and intraperitoneal administration of ovocystatin, Coloco and Colostrinin in the group of old rats. CONCLUSIONS: The obtained results suggest that oral administration of ovocystatin and Coloco has beneficial effects on the cognitive functions of young rats.

Compensatory functional reorganization may precede hypertension-related brain damage and cognitive decline: a functional magnetic resonance imaging study.

OBJECTIVES: Our study aimed at exploring structural and functional differences in the brain during higher cognitive processing between middle-aged hypertensive patients and controls matched for sex, age and years of education. METHODS: Two groups of 20 patients took part in MRI examinations. This article reports the results of functional MRI during a Stroop color interference task and structural evaluations based on a modified Fazekas scale. RESULTS: No intergroup differences were found in regards to the severity of white matter lesions (Mann-Whitney U test = 150.5, P > 0.1), nor from the task performance in the scanner (t(35) = 0.2, P > 0.1). However, brain activation patterns between patients and controls varied. Hypertensive patients involved significantly more cerebral areas during the processing, regardless of the task difficulty. Differences were found in 26 diverse regions of both primary and associative cortices (with a peak voxel located in the cuneus, Z = 6.94, P < 0.05 family-wise error corrected at voxel level). CONCLUSION: Our findings provide an insight into the brain mechanisms related to essential hypertension and suggest a functional reorganization (neuroplasticity) early in the course of the disease.

Pro-Cognitive Properties of the Immunomodulatory Polypeptide Complex, Yolkin, from Chicken Egg Yolk and Colostrum-Derived Substances: Analyses Based on Animal Model of Age-Related Cognitive Deficits.

The study aimed to assess the effect of the polypeptide Y complex (Yolkin), isolated from chicken egg yolk, on behavioural and cognitive functions. It also aimed to compare this activity with colostrum-derived substances (Colostrinin, Coloco), which have a confirmed impact on learning and memory. In the study, the effect of Yolkin, administered to rats of different ages, who performed various tasks involving spatial and episodic memory, motor functions and exploratory behavior, was assessed. The experiment was carried out in rats which were 6 and 12 months old. Two different doses of the studied specimens based on previous comparative studies and two different routes of administration (oral and retroperitoneal) were used. A series of behavioural tests were carried out, including an open field test, a novel object recognition test and a Morris water maze. They were used to evaluate the impact of the studied specimen on improving locomotor function and exploratory behaviour, preventing their decline and assess the functioning of episodic and spatial memory in aging rats. The administration of Yolkin gave distinct effects compared to colostrum-derived substances, although confirmed its suggested pro-cognitive action. Therefore, it may be used to enhance cognitive functions and inhibit the progression of dementia in the course of neurodegenerative disorders.