RESUMO
Tinnitus is the perception of hearing the sound without any sound stimulus. It is a symptom of abnormality in a form of conductive disorder when it comes from the outer ear canal and middle ear. A tinnitus complaint has a normal hearing threshold but it has been not fully recognized its causes. Thus, an objective evaluation is needed to locate the abnormality by using OAE and BERA test. To analyze the association of TEOAE, DPOAE, and BERA to locate cochlear and retrocochlear disorders in tinnitus patients with normal hearing threshold. The study was conducted from August to November 2010 until the number of samples was fulfilled in Outpatient Clinic and Audiology Unit in Department of Otolaryngology-Head and Neck Surgery, Dr. Soetomo General Hospital Surabaya. The inclusion criteria in this study included: patients aged 20-50 years old, hearing threshold of ≤ 25 dB, type A tympanogram. The comparison and the association test of TEOAE, DPOAE and BERA in tinnitus group were: TEOAE-BERA analysis result using Mc Nemar obtained p = 0.006, Kappa p = 0.047, likelihood ratio p = 0.066, and the result of DPOAE-BERA analysis using Mc Nemar obtained p = 0.008, Kappa p = 0.439, likelihood ratio p = 0.336. There was a difference in the results of DPOAE examination between tinnitus patients with normal hearing threshold and the control group. There was no difference in TEOAE and BERA test results between tinnitus patients with normal hearing threshold and the control group. This indicates an abnormality in the cochlear.
RESUMO
Nasopharyngeal carcinoma (NPC) is a malignant disease originating from the nasopharyngeal epithelial cells. The molecular mechanism of cancer occurrence is a change in the oncogene and tumor suppressor genes. One of the tumor suppressor genes that mutate in cancer cells is the mutant p53 gene. One of nasopharyngeal carcinoma progression is determined by the status of regional lymph gland. The enormous regional lymph node has a poor prognosis. To analyze the expression of the mutant p53 protein in Nasopharyngeal carcinoma (NPC) that correlated with regional lymph gland status (N) as a clinical manifestation. Expression of mutant p53 protein from NPC tissue paraffin block with immunohistochemical cracking technique was using monoclonal rabbit Anti Human p53 clone 318-6-11 (Dako, North America, Inc., 6392 Via Real Carpinteria, CA 93013 USA), microscope light binoculars was assessed visually by an Anatomical Pathology Consultant. Positive expression of p53 mutants was obtained 57.58% from all the sample in N0 by 0 subjects, N1 was 6 subjects, N2 was 7 subjects, and N3 was 7 subjects. The results of Mann-Whitney U test was p = 0.706, then there was no significant (p > 0.05) correlation between positive expression of p53 protein in type III WHO NPC with the regional lymph gland were N0, N1, N2, and N3. There was no significant between expression protein p53 mutants' regional and lymph gland in type III WHO NPC.
