RESUMO
Three cases involving overdoses of carisoprodol are presented. Concentrations of carisoprodol and its major metabolite meprobamate, were determined in urine, vitreous humor, heart, and femoral blood. All drugs were quantified by gas chromatography/mass spectrometry (GC/MS).
Assuntos
Carisoprodol/farmacocinética , Adulto , Carisoprodol/análise , Carisoprodol/intoxicação , Feminino , Cromatografia Gasosa-Espectrometria de Massas , Humanos , Indicadores e Reagentes , Masculino , Meprobamato/análise , Meprobamato/sangue , Meprobamato/urina , SuicídioRESUMO
A case involving an overdose fatality of cyclizine is presented. Toxicological analysis revealed a cyclizine blood concentration of 80 micrograms/mL. The drug was quantified by gas chromatography/mass spectrometry (GC/MS). Qualitative analyses of urine and stomach contents were performed.
Assuntos
Ciclizina/intoxicação , Adolescente , Cromatografia em Camada Fina , Ciclizina/análise , Ciclizina/sangue , Overdose de Drogas , Feminino , Cromatografia Gasosa-Espectrometria de Massas , Conteúdo Gastrointestinal/análise , HumanosRESUMO
A 26-year-old woman committed suicide by ingestion of a large quantity of tocainide, a recently developed oral antiarrhythmic agent with chemical similarities to lidocaine. Blood and bodily fluid analysis by thin-layer chromatography, high pressure liquid chromatography, and mass spectroscopy confirmed the presence of tocainide, with a serum level of 68 mg/L, nearly 7 times the upper recommended therapeutic level for this drug. Tocainide was also detected at significant levels in vitreous fluid and bile. Although the mechanism of death from tocainide intoxication in animal studies is related to central nervous system toxicity, the presentation of ventricular tachyarrhythmias with coma in this patient suggests that tocainide at high levels may have primary myocardiotoxicity in humans.
