[Results of treatment with interferon for chronic hepatitis B in children]. / Wyniki leczenia interferonem przewleklego wirusowego zapalenia watroby typu B u dzieci.

8 children with chronic hepatitis B were treated with interferon, 3 M.U. subcutaneously three times a week for 4-5 months. Seroconversion from HBe antigen to anti HBe antibodies was observed in 3 of them and in 1 also seroconversion from HBs antigen to anti HBs antibodies. In remaining 5 cases the therapy was ineffective which could be caused by: more advanced inflammatory lesions in liver, infection with HB in infancy and low activity of aminotransferases before the treatment. Side effects of interferon were only transitory and in no case caused cessation of the therapy.

[Markers of chronic hepatitis B in children after completion of therapy with isoprinosine]. / Wykladniki aktywnosci przewleklego zapalenia watroby typu B u dzieci po zakonczeniu leczenia izoprynozyna.

Fourteen children with chronic active hepatitis B treated with isoprinosine were followed-up for 3-8 years. In no child HBs antigen was eliminated. No seroconversion was noted in children in whom HBe antigen was eliminated. Anti-HBe antibodies were found in 11 children, including 6 children in whom they were present all the time following therapy, and 2 children in whom these antibodies reappeared after an initial elimination. These results suggest that the inhibition of hepatitis B virus replication produced by isoprinosine may be transient. Therefore, longer lasting immunomodulating therapy should be considered.

[Incubation period of varicella in children with neoplastic diseases]. / Okres wylegania ospy wietrznej u dzieci z chorobami nowotworowymi.

Duration of varicella incubation period has been analysed in 21 pediatric patients with neoplastic diseases and in 59 children without immunological deficiency. In has been found, that incubation period has been significantly longer in children with neoplastic diseases (mean 19.58 days), than that in children without immunologic disorders (15.45 days). The difference was statistically significant (p < 0.001).

[Results of acyclovir treatment of chickenpox and herpes zoster in children with immune tolerance]. / Wyniki leczenia acyklowirem ospy wietrznej i pólpasca u dzieci ze zmniejszona odpornoscia immunologiczna.

Acyclovir was used for the treatment of Varicella-zoster virus infections in 53 children (10 neonates and 43 children aged between 2 an 15 years) with immunological system deficiency hospitalized at the Department of the Infectious Diseases of Childhood in the Medical Academy in Warszawa. The obtained results of therapy were favourable except one fatal case of the child with visceral dissemination of the virus prior to acyclovir treatment. Compared with other antiviral agents used by the authors previously, acyclovir proved to be the most effective.