Vulvovaginal graft-versus-host disease: a review.

Hematopoietic cell transplantation (HCT) is associated with well-described gynecologic sequelae, including vulvovaginal graft-versus-host disease (GVHD). Vulvovaginal GVHD is a common complication of allogeneic HCT, but has been under-reported in the literature. Guidelines have been published only recently to recommend common terminology, treatment, and surveillance. This review summarizes the presentation, management, and surveillance aspects of vulvovaginal GVHD. We recommend a standardized referral between women undergoing HCT and an experienced gynecologist capable of managing this disease and treating sexual side effects.

Laparoscopy in children and adolescents.

One hundred twelve females below the age of twenty years underwent laparoscopy at the Medical University of South Carolina over a ten-year period. Pelvic pain followed by primary amenorrhea was the major indication for the procedure. Eighty-nine percent of those with acute pain had identifiable pelvic pathology, whereas 27% of girls presenting with chronic pain had a normal laparoscopic examination. Pelvic inflammatory disease was the most common diagnosis. Ovarian cysts, pregnancy complications, and endometriosis were also found. Endometriosis was not found among black teenage clinic patients. The procedure appears to be a safe and useful diagnostic tool in this age group.