RESUMO
One hundred eighty-two Balinese were typed for HLA-A and -B locus antigens. From these, 103 were also typed for HLA-C, 51 for HLA-DR, 172 for Bf and 173 for GLO. These results and the significant phenotypic associations are situated with respect to other South-East Asian populations. In addition to this first study, 175 individuals from an isolated Balinese village typed for HLA-A, -B, -DR, Bf and GLO are presented. The effect of isolation on haplotype (HLA-A/-B/Bf/-DR) variability is discussed.
Assuntos
Antígenos HLA/genética , Sudeste Asiático , Consanguinidade , Feminino , Frequência do Gene , Genes MHC da Classe II , Genética Populacional , Antígenos HLA-A , Antígenos HLA-B , Antígenos HLA-C , Antígenos HLA-DR , Humanos , Indonésia , Masculino , Ilhas do PacíficoRESUMO
A monoclonal antibody, FMC 5, has been prepared against human lymphocytes and its reactivity examined. FMC 5 behaves, for the most part, as an anti-HLA-A2 typing serum. However, three small groups of discrepant types were identified, and each provides additional insight into the complexity of the MHC antigens. A small number (5/60) of donors typed as HLA-A2 did not react with FMC 5. A further group (6/35) were HLA-A2 and did react with FMC 5, but lysis was always incomplete in this group. Finally, 13/39 non-A2 donors gave various degrees of reactivity with FMC 5. Lysis in this group was usually incomplete and required a high antibody concentration.
Assuntos
Anticorpos Monoclonais/imunologia , Antígenos HLA/genética , Polimorfismo Genético , Animais , Especificidade de Anticorpos , Reações Antígeno-Anticorpo , Antígenos HLA/imunologia , Humanos , Linfócitos/imunologia , Camundongos , Camundongos Endogâmicos C57BL/imunologiaRESUMO
Forty-four patients with inflammatory demyelinating polyneuritis (22 with Landry-Guillain-Barré syndrome, 6 with subacute polyneuritis, and 16 with chronic relapsing polyneuritis) were typed for genetic markers in and around the HLA region of chromosome 6. Patients with chronic relapsing polyneuritis showed a definite association with HLA-AW30 and AW31 and probable associations with HLA-B8, HLA-DW3, and glyoxalase I. No significant associations were demonstrated with the Landry-Guillain-Barré syndrome although an increase in glyoxalase I was significant if combined with the results of typing in chronic relapsing polyneuritis. The total patient group showed significant increases in HLA-AW30, HLA-AW31, and HLA-DW3. The results support the view that HLA-linked genetic factors influence susceptibility to chronic relapsing polyneuritis and may contribute to the differences in clinical patterns observed in inflammatory demyelination of the peripheral nervous system.
