Prognostic significance of imaging features of peritumoral adipose tissue in FDG PET/CT of patients with colorectal cancer.

PURPOSE: This study investigated the relationship of imaging features of primary tumor and peritumoral VAT on PET/CT with histopathological findings of peritumoral VAT and recurrence-free survival (RFS) in patients with colorectal cancer. METHODS: We retrospectively reviewed 133 patients diagnosed with colorectal cancer who underwent staging FDG PET/CT and received curative surgery. Histogram-based imaging features of primary tumor and peritumoral VAT were extracted from PET/CT images. Based on histopathological analysis of peritumoral VAT, the degree of CD4, CD8, and CD163 cell infiltration and the expression of matrix metalloproteinase-11 and interleukin 6 (IL-6) were graded. Differences in imaging parameters based on the histopathological results and the relationships between imaging features and RFS were assessed. RESULTS: Mean CT-attenuation and SUV of peritumoral VAT showed significant positive correlation with CD163 cell infiltration and IL-6 expression of peritumoral VAT. Univariable survival analysis revealed significant correlation between RFS and the mean CT-attenuation, mean SUV, and first-order SUV entropy of peritumoral VAT (p < 0.05). Multivariable analysis indicated that mean SUV and SUV entropy of peritumoral VAT remained significant predictors of RFS after adjustment for age, sex, and T stage (p < 0.05). CONCLUSION: FDG uptake of peritumoral VAT was significantly associated with inflammatory response in peritumoral VAT and was an independent predictor of RFS in colorectal cancer patients.

The preliminary study of differentiating osteoporotic fractured group from nonfractured group.

Osteoporosis is characterized by an abnormal loss of bone mineral content, which leads to a tendency to nontraumatic bone fractures or to structural deformations of bone. Thus bone density measurement has been considered as a most reliable method to assess bone fracture risk due to osteoporosis. In past decades bone texture measures have been also studied in connection with the bone quality estimation. However, most studies have been focused on texture analysis of CT or MR images. Though studies on plain radiographs have been also performed to assess in vivo trabecular structure these studies are mainly done on anatomic sites such as femur, spine, and calcaneus. In this preliminary study we apply various texture measures to distal radius plain radiographs and point out several promising texture measures that significantly distinguish between osteoporotic fractured group and nonfractured group.

Computer-assisted Sonographic Analysis of the Hepatorenal and Textural Features for the Diagnosis of the Fatty Liver.

We investigated the B-mode ultrasound (US) images of abdomen by normalizing the gray level values of the liver with the representative gray levels (RGL's) of the liver parenchyma, renal cortex, subcutaneous fat, to quantify the fatty infiltration of the liver (FIL). The RGL's were compared with the clinical diagnosis of the FIL showing good correlation between them.