RESUMO
Aneurysms of the splenic artery are the most common visceral aneurysm. A splenomesenteric trunk, which involves the splenic artery arising from the superior mesenteric artery (SMA), is rare and occurs in less than 1% of patients. Thus splenic artery aneurysms (SAAs) with an anomalous origin from the SMA are quite rare. We report our experience with the surgical management of a 2.6-cm aneurysm involving a splenic artery arising from the SMA in a 40-year-old woman. This was treated with surgical resection with preservation of the spleen. A discussion about SAAs and the management of aneurysms arising from a splenomesenteric trunk follows.
RESUMO
Aneurysms of the splenic artery are the most common visceral aneurysm. A splenomesenteric trunk, which involves the splenic artery arising from the superior mesenteric artery (SMA), is rare and occurs in less than 1% of patients. Thus splenic artery aneurysms (SAAs) with an anomalous origin from the SMA are quite rare. We report our experience with the surgical management of a 2.6-cm aneurysm involving a splenic artery arising from the SMA in a 40-year-old woman. This was treated with surgical resection with preservation of the spleen. A discussion about SAAs and the management of aneurysms arising from a splenomesenteric trunk follows.
Assuntos
Aneurisma/congênito , Artéria Mesentérica Superior/anormalidades , Artéria Esplênica/anormalidades , Adulto , Idoso , Aneurisma/diagnóstico , Aneurisma/cirurgia , Feminino , Humanos , Masculino , Artéria Mesentérica Superior/diagnóstico por imagem , Artéria Mesentérica Superior/cirurgia , Pessoa de Meia-Idade , Radiografia , Artéria Esplênica/diagnóstico por imagem , Artéria Esplênica/cirurgia , Resultado do Tratamento , Procedimentos Cirúrgicos VascularesRESUMO
Acute aortic occlusion is an uncommon vascular emergency that can present with predominantly neurologic symptoms owing to spinal cord ischemia. We describe a 62-year-old woman who experienced acute thrombosis of an abdominal aortic aneurysm that initially presented as cauda equina syndrome. She was treated operatively with an axillary bifemoral bypass. Our case report is followed by a discussion of acute aortic occlusion.
Assuntos
Aneurisma da Aorta Abdominal/complicações , Arteriopatias Oclusivas/etiologia , Polirradiculopatia/etiologia , Isquemia do Cordão Espinal/etiologia , Trombose/etiologia , Doença Aguda , Anticoagulantes/uso terapêutico , Aneurisma da Aorta Abdominal/diagnóstico , Aneurisma da Aorta Abdominal/cirurgia , Aortografia/métodos , Arteriopatias Oclusivas/diagnóstico , Arteriopatias Oclusivas/cirurgia , Artéria Axilar/cirurgia , Feminino , Artéria Femoral/cirurgia , Humanos , Polirradiculopatia/diagnóstico , Polirradiculopatia/cirurgia , Isquemia do Cordão Espinal/diagnóstico , Isquemia do Cordão Espinal/cirurgia , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Enxerto VascularRESUMO
Trauma and Injury Severity Score (TRISS) has been the benchmark of mortality risk in trauma centers for over 30 years. TRISS utilizes the Injury Severity Score (ISS) as an index of anatomical injury. This study investigated the efficacy of a new type of index of anatomical injury called the ICD-derived Injury Severity Score (ICISS) compared to the ISS using a logistic regression analysis and a global chi-square test of the areas under the Receiver Operator Characteristic (ROC) curves. We found that the empirically derived ICISS performed as well as the consensus derived ISS with no statistical differences between their respective area under the ROC curves.
RESUMO
When given orally to a transgenic mouse model of Alzheimer disease, cyclohexanehexol stereoisomers inhibit aggregation of amyloid beta peptide (Abeta) into high-molecular-weight oligomers in the brain and ameliorate several Alzheimer disease-like phenotypes in these mice, including impaired cognition, altered synaptic physiology, cerebral Abeta pathology and accelerated mortality. These therapeutic effects, which occur regardless of whether the compounds are given before or well after the onset of the Alzheimer disease-like phenotype, support the idea that the accumulation of Abeta oligomers has a central role in the pathogenesis of Alzheimer disease.
