RESUMO
Peripheral blood stem cells (PBSC) are rapidly replacing bone marrow cells for autologous transplantation. This introduction, largely without randomized prospective trials, has occurred because of the ease of PBSC collection and the associated rapid haematological recovery with its lower costs and reduced blood product exposure. The administration of haematopoietic growth factors during recovery from high-dose chemotherapy increases the number of circulating haematopoietic progenitor cells to levels 1000-fold greater than levels normally found in blood. The CD34+ cell number, CFU-GM and CFU-Meg are commonly employed parameters used to assess the quality of PBSC harvests. This review examines the impact that PBSCT has had on haematological practice and patient care illustrated by our local practice in Cardiff.
Assuntos
Neoplasias Hematológicas/terapia , Transplante de Células-Tronco Hematopoéticas , Transfusão de Plaquetas , Animais , Plaquetas/citologia , Plaquetas/fisiologia , HumanosRESUMO
Substance abuse frequently accompanies and complicates serious traumatic brain injury (TBI). An important prerequisite to providing assistance to TBI patients is the ability to identify substance abuse accurately. The authors prospectively evaluated 10 consecutive admissions to a TBI program using four substance abuse screening tools: the CAGE questions, the Brief Michigan Alcohol Screening Test (BMAST), the Substance Abuse Subtle Screening Inventory, and the Addiction Severity Index. The CAGE questions and the BMAST were found to be easy to administer and very sensitive as well as specific for substance abuse in this population. The authors conclude that all patients with traumatic brain injuries should be screened for substance abuse by using either the CAGE questions or the BMAST.
Assuntos
Lesões Encefálicas/epidemiologia , Inventário de Personalidade/estatística & dados numéricos , Psicotrópicos , Detecção do Abuso de Substâncias/estatística & dados numéricos , Transtornos Relacionados ao Uso de Substâncias/epidemiologia , Adulto , Lesões Encefálicas/psicologia , Comorbidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pennsylvania/epidemiologia , Projetos Piloto , Estudos Prospectivos , Reprodutibilidade dos Testes , Transtornos Relacionados ao Uso de Substâncias/psicologiaRESUMO
Studies have associated insecticides used for spruce budworm control with Reye's syndrome. In Maine, spruce budworm insecticide spraying began in 1954, and an annual spray program was started in 1972. Reye's syndrome incidence information (1978-1982), obtained from hospital discharge data, death certificates, and reports to the Bureau of Health, was compared with the geographic distribution of spruce budworm insecticide spraying. No association between Reye's syndrome and spruce budworm spraying was found, although some geographic clustering of Reye's syndrome cases was observed.
