A Case of Mixed Germ Cell Tumor of Ovary: Complete Remission after Conservative Surgery and Bleomycin, Etoposide, Cisplatin (BEP) therapy / 대한산부인과학회잡지

Malignant germ cell tumor of ovary is very rare and one of the most malignant gynecologic neoplasms usually affecting younger women. we experienced a case of 19-year old female with mixed germ cell tumor of ovary which was composed of endodermal sinus tumor and dysgerminoma. we report this case with a brief review of the literature.

A Case Of Intraperitoneal Hemorrhage Of Intraligamentary Pregnancy / 대한산부인과학회잡지

A case of intraperitoneal hemorrhage of intraligamentary pregnancy is one of the most unusual accidents in obstetrics and carries a high degree of maternal and fetal morbity and mortality. The diagnosis of intraligamentary pregnancy is rarely ever made prior to laparotomy. We report a case of it with a brief review of literatures concerned.

A Case Of Squamous Cell Carcinoma Arising In Mature Cystic Teratoma Of Left Ovary / 대한산부인과학회잡지

Mature cystic teratoma of the ovary is the most common ovarian germ cell neoplasm representing 10-20% of all ovarian tumors. Malignant transformation rarely takes place, which is approximately 1-2% of all cases. The most common malignancy arising in mature cystic teratoma is squamous cell carcinoma. The prognosis of malignant transformation developing in mature cystic teratoma is poor and the management is not established due to the rarity of malignant degeneration. A case of stage Ia squamous cell carcinoma which developed in mature cystic teratoma of left ovary in a 43-year-old female is presented. The ovarian tumor was woman's fist-sized with intact capsule. Left oophorocystectomy was done. Above case with a brief review of literature is given.

The effect of the sera from severe preeclamptic patients on endothelial cell viability and endothelin-1 in cultured human umbilical vein endothelial cells / 대한산부인과학회잡지

OBJECTIVES: In order to assess the effects of sera from severe preeclamptic patients on endothelial cell viability in vitro and endothelin-1 synthesis in cultured human umbilical vein endothelial cells. METHODS: The cultured human umbilical vein endothelial cells were incubated with media containing 10% sera from women with either preeclamptic patients or normal pregnancies for 24 hours or 48 hours. After then, their viability was measured by colorimetric MTT{3-(4,5-dimethylthiazol-2yl)2,5-diphenyl tetrazolium bromide} assay and their production of endothelin-1 was measured. We also measured the serum levels of endothelin-1 level in sera obtained from the normal and severe preeclamptic pregnancies. RESULTS: The calorimetric MTT assay revealed that after 24 hours, the absorbances in the media treated with normal pregnancies and severe preeclampsia sera were 0.0718+/-0.0078 and 0.0837+/-0.0129, respectively and after 48 hours, they were 0.1133+/-0.0103 and 0.1268+/-0.0186, respectively. Serum obtained from severe preeclampsia did not affect endothelial cell viability. 2. The serum mean levels of endothelin-1 in normal and severe preeclamptic pregnancies were 22.66+/-8.6 fmol/ml and 48.98+/-25.27 fmol/ml. The mean level in preeclamptic sera was significantly higher than that of normal pregnant women. (P<0.05) 3. After 24 hours, the mean amount of endothelin-1 stimulated by normal pregnant and severe preeclamptic sera were 37.52+/-18.41 fmol/ml and 97.58+/-53.64 fmol/ml, respectively. The mean amount of endothelin-1 in preeclamptic sera-treated cells was significantly higher than that of normal pregnant sera-treated cells. (P<0.05). CONCLUSION: The sera from severe preeclamptic women do not affect cell viability but act selectively on specific activation of their function such as endothelin-1 production. And it is necessary that the identification and isolation of the putative serum factor(s) will be performed to resolve the pathogenesis in future.