[Strategic cytogenetic aids in oncologic diagnosis and individual therapy control]. / Strategische zytogenetische Hilfen für die onkologische Diagnostik und eine individuelle Therapieführung.

The main cytogenetic markers of haemoblastoses and other myelo- and lymphoproliferative disorders as well as an oncologically relevant gene map of the human chromosomes were demonstrated taking as a basis own data and corresponding literature. We have tried to describe the current prognostic value of several karyotypic traits and trends for the use of clinicians, especially for oncologists, from the cytogenetic point of view. We particularly consider the dynamics and the development, the competition between various cell-lines of the bone-marrow with different changes of the karyotypes. Further attempts to a clear understanding of the nature and the significance of clonal chromosome changes in haemoblastoses and other tumours as well as of the risk of neoplastic development determined by distinct chromosomal abnormalities should take into consideration the molecular mechanisms of translocation and also the consequences of gene dosis, such as of immunologic systems. At present cytogenetic tumour markers seem to be a strategic aid for diagnosis and prognosis as well as for the understanding of the mechanisms, initiating the chromosome aberrations and leading to further changes during the development of the tumour.

[Hereditary polyposis]. / Hereditäre Polyposis.

1. The familial polyposis coli is a precancerosis. At an age of about 40 years the majority of the untreated carriers of symptoms dies of the malignant degeneration of a multiple polyp in colon and rectum. The only promising therapy is the possibly extensive removal of all polyps. Only the early total or subtotal colectomy, the latter with an ileorectal anastomosis, come into consideration. In these cases a life-long control of the rectum is necessary. The heredity is dominantly autosomal. 2. In the Peutz-Jeghers-syndrome numerous. In most cases benign polyps are found in all parts of the gastrointestinal tract, above all in the small intestine. Complications are haemorrhages and invaginations due to weakness of the connective tissue of the intestinal wall. Resections of the intestine are necessary only in appearances of the ileus. The diagnosis can easily be made at the above all perioral pigment patches. Irregularly dominant heredity. On the basis of two own family observations the importance of the genetic family consultation is emphasized.

[Problems of hepatitis in dialysis patients, technical personnel and their relatives]. / Zur Problematik der Hepatitiserkrankungen bei Dialysepatienten, Personal und Angehörigen

In a centre for dialytic treatment of the district Karl-Marx-Stadt during 16 months patients and staff underwent a continuous clinico-epidemiological observation. By means of determinations of serum enzymes and Au-antigen-investigation regularly carried out in these cases the special risk of hepatitis could be confirmed. Hygienic-antiepidemic and organization measures are discussed and recommendations are given concerning the prophylactically more aimed course. Further investigations are necessary in as far as certain basic diseases (i.g., renal insufficiency) have an influence on the Au-antigen-persistence by impairment of the immune system and which epidemiological effects may result from this.