RESUMO
We investigate how to improve new physics detection strategies exploiting variational autoencoders and normalizing flows for anomaly detection at the Large Hadron Collider. As a working example, we consider the DarkMachines challenge dataset. We show how different design choices (e.g., event representations, anomaly score definitions, network architectures) affect the result on specific benchmark new physics models. Once a baseline is established, we discuss how to improve the anomaly detection accuracy by exploiting normalizing flow layers in the latent space of the variational autoencoder.
RESUMO
In the particle detectors at the Large Hadron Collider, hundreds of millions of proton-proton collisions are produced every second. If one could store the whole data stream produced in these collisions, tens of terabytes of data would be written to disk every second. The general-purpose experiments ATLAS and CMS reduce this overwhelming data volume to a sustainable level, by deciding in real-time whether each collision event should be kept for further analysis or be discarded. We introduce a dataset of proton collision events that emulates a typical data stream collected by such a real-time processing system, pre-filtered by requiring the presence of at least one electron or muon. This dataset could be used to develop novel event selection strategies and assess their sensitivity to new phenomena. In particular, we intend to stimulate a community-based effort towards the design of novel algorithms for performing unsupervised new physics detection, customized to fit the bandwidth, latency and computational resource constraints of the real-time event selection system of a typical particle detector.
RESUMO
Graph neural networks have been shown to achieve excellent performance for several crucial tasks in particle physics, such as charged particle tracking, jet tagging, and clustering. An important domain for the application of these networks is the FGPA-based first layer of real-time data filtering at the CERN Large Hadron Collider, which has strict latency and resource constraints. We discuss how to design distance-weighted graph networks that can be executed with a latency of less than one µs on an FPGA. To do so, we consider a representative task associated to particle reconstruction and identification in a next-generation calorimeter operating at a particle collider. We use a graph network architecture developed for such purposes, and apply additional simplifications to match the computing constraints of Level-1 trigger systems, including weight quantization. Using the hls4ml library, we convert the compressed models into firmware to be implemented on an FPGA. Performance of the synthesized models is presented both in terms of inference accuracy and resource usage.
RESUMO
Cancers are one of the leading causes of deaths affecting millions of people around the world, therefore they are currently a major public health problem. The treatment of cancer is based on surgical resection, radiotherapy, chemotherapy or immunotherapy, much of which is often insufficient and cause serious, burdensome and undesirable side effects. For many years, assorted secondary metabolites derived from plants have been used as antitumor agents. Recently, researchers have discovered a large number of new natural substances which can effectively interfere with cancer cells' metabolism. The most famous groups of these compounds are topoisomerase and mitotic inhibitors. The aim of the latest research is to characterize natural compounds found in many common foods, especially by means of their abilities to regulate cell cycle, growth and differentiation, as well as epigenetic modulation. In this paper, we focus on a review of recent discoveries regarding nature-derived anticancer agents.