Patient-Specific Bone Multiscale Modelling, Fracture Simulation and Risk Analysis-A Survey.

This paper provides a starting point for researchers and practitioners from biology, medicine, physics and engineering who can benefit from an up-to-date literature survey on patient-specific bone fracture modelling, simulation and risk analysis. This survey hints at a framework for devising realistic patient-specific bone fracture simulations. This paper has 18 sections: Section 1 presents the main interested parties; Section 2 explains the organzation of the text; Section 3 motivates further work on patient-specific bone fracture simulation; Section 4 motivates this survey; Section 5 concerns the collection of bibliographical references; Section 6 motivates the physico-mathematical approach to bone fracture; Section 7 presents the modelling of bone as a continuum; Section 8 categorizes the surveyed literature into a continuum mechanics framework; Section 9 concerns the computational modelling of bone geometry; Section 10 concerns the estimation of bone mechanical properties; Section 11 concerns the selection of boundary conditions representative of bone trauma; Section 12 concerns bone fracture simulation; Section 13 presents the multiscale structure of bone; Section 14 concerns the multiscale mathematical modelling of bone; Section 15 concerns the experimental validation of bone fracture simulations; Section 16 concerns bone fracture risk assessment. Lastly, glossaries for symbols, acronyms, and physico-mathematical terms are provided.

Numerical investigation of design parameters for optimization of the in-situ ultrasonic fouling removal technique for pipelines.

Fouling build-up in engineering assets is a known problem and, as a solution, the application of power ultrasonic for in-situ fouling removal has gained much attention from the industry. Current state-of-the-art fouling removal includes the use of hydraulic, chemical and manual techniques. Much research has been conducted to advance the knowledge on the potential uses of ultrasonics across different fouling applications, primarily in reverse osmosis membranes and heat exchangers. However, the optimization of in-situ ultrasonic fouling removal has not yet been investigated and is still in its infancy. The present study uses a previously experimentally-validated numerical model to conduct a parametric study in order to optimize the technique. Focus was given to the adoption of ultrasonics for large diameter pipes. Therefore, this investigation was conducted on a 6 in. schedule 40-carbon steel pipe. Parameters investigated include: optimum number of transducers to remove fouling in long pipes from a single transducer location; performance at elevated temperature; different fluid domains; optimum voltage; variety of input signals and incremental thickness of fouling. Depending on the particular studied conditions, the possible fouling removal of up to +/-3 m from a single transducer location is demonstrated in a 6 in. schedule 40 carbon steel pipe.

A thermoregulation model for whole body cooling hypothermia.

This paper presents a thermoregulation model based on the finite element method to perform numerical analyses of brain cooling procedures as a contribution to the investigation on the use of therapeutic hypothermia after ischemia in adults. The use of computational methods can aid clinicians to observe body temperature using different cooling methods without the need of invasive techniques, and can thus be a valuable tool to assist clinical trials simulating different cooling options that can be used for treatment. In this work, we developed a finite element method (FEM) package using isoparametric linear three-dimensional elements which is applied to the solution of the continuum bioheat Pennes equation. Blood temperature changes were considered using a blood pool approach and a lumped analysis for intravascular catheter methods of blood cooling. Some analyses are performed using a three-dimensional mesh based on a complex geometry obtained from computed tomography medical images, considering a cooling blanket and an intravascular catheter. A comparison is made between the results obtained with the two techniques and the effects of each case in brain temperature reduction in a required period of time, maintenance of body temperature at moderate hypothermia levels and gradual rewarming.

Characterization of the Use of Low Frequency Ultrasonic Guided Waves to Detect Fouling Deposition in Pipelines.

The accumulation of fouling within a structure is a well-known and costly problem across many industries. The build-up is dependent on the environmental conditions surrounding the fouled structure. Many attempts have been made to detect fouling accumulation in critical engineering structures and to optimize the application of power ultrasonic fouling removal procedures, i.e., flow monitoring, ultrasonic guided waves and thermal imaging. In recent years, the use of ultrasonic guided waves has been identified as a promising technology to detect fouling deposition/growth. This technology also has the capability to assess structural health; an added value to the industry. The use of ultrasonic guided waves for structural health monitoring is established but fouling detection using ultrasonic guided waves is still in its infancy. The present study focuses on the characterization of fouling detection using ultrasonic guided waves. A 6.2-m long 6-inch schedule 40 carbon steel pipe has been used to study the effect of (Calcite) fouling on ultrasonic guided wave propagation within the structure. Parameters considered include frequency selection, number of cycles and dispersion at incremental fouling thickness. According to the studied conditions, a 0.5 dB/m drop in signal amplitude occurs for a fouling deposition of 1 mm. The findings demonstrate the potential to detect fouling build-up in lengthy pipes and to quantify its thickness by the reduction in amplitude found from further numerical investigation. This variable can be exploited to optimize the power ultrasonic fouling removal procedure.

Numerical modelling of acoustic pressure fields to optimize the ultrasonic cleaning technique for cylinders.

Fouling build up is a well-known problem in the offshore industry. Accumulation of fouling occurs in different structures, e.g. offshore pipes, ship hulls, floating production platforms. The type of fouling that accumulates is dependent on environmental conditions surrounding the structure itself. Current methods deployed for fouling removal span across hydraulic, chemical and manual, all sharing the common disadvantage of necessitating halting production for the cleaning process to commence. Conventionally, ultrasound is used in ultrasonic baths to clean a submerged component by the generation and implosion of cavitation bubbles on the fouled surface; this method is particularly used in Reverse Osmosis applications. However, this requires the submersion of the fouled structure and thus may require a halt to production. Large fouled structures such as pipelines may not be accommodated. The application of high power ultrasonics is proposed in this work as a means to remove fouling on a structure whilst in operation. The work presented in this paper consists of the development of a finite element analysis model based on successful cleaning results from a pipe fouled with calcite on the inner pipe wall. A Polytec 3D Laser Doppler Vibrometer was used in this investigation to study the fouling removal process. Results show the potential of high power ultrasonics for fouling removal in pipe structures from the wave propagation across the structure under excitation, and are used to validate a COMSOL model to determine cleaning patterns based on pressure and displacement distributions for future transducer array design and optimization.

A thermoregulation model for hypothermic treatment of neonates.

This paper presents a thermoregulation finite element model (FEM) to simulate hypothermia procedures for the treatment of encephalopathy hypoxic-ischemia (EHI) in neonates, a dangerous ischemic condition that can cause neurological damages and even death. Therapeutic hypothermia is the only recommended technique to reduce sequels caused by EHI in neonates; intervention with moderate cooling for neural rescue in newborns with hypoxic-ischemic brain injury is the culmination of a series of clinical research studies spanning decades. However, the direct monitoring of brain cooling is difficult and can lead to additional tissue damage. Therefore, the measurement of efficiency during clinical trials of hypothermia treatment is still challenging. The use of computational methods can aid clinicians to observe the continuous temperature of tissues and organs during cooling procedures without the need for invasive techniques, and can thus be a valuable tool to assist clinical trials simulating different cooling options that can be used for treatment. The use of low cost methods such as cooling blankets can open the possibility of using brain cooling techniques in hospitals and clinics that cannot currently afford the available expensive equipment and techniques. In this work, we developed a FEM package using isoparametric linear three-dimensional elements which is applied to the solution of the continuum bioheat Pennes equation. Blood temperature changes were considered using a blood pool approach. The results of the FEM model were compared to those obtained through the implementation of a user-defined function (UDF) in the commercial finite volume software FLUENT and validated with experimental tests. Numerical analyses were performed using a three-dimensional mesh based on a complex geometry obtained from MRI scan medical images.

Modelling and optimisation of the operation of a radiant warmer.

This paper presents numerical calculations of the temperature field obtained for the case of a neonate placed under a radiant warmer. The results of the simulations show a very non-uniform temperature distribution on the skin of the neonate, which may cause increased evaporation leading to severe dehydration. For this reason, we propose some modifications on the geometry and operation of the radiant warmer, in order to make the temperature distribution more uniform and prevent the high temperature gradients observed on the surface of the neonate. It is concluded that placing a high conductivity blanket over the neonate and introducing additional screens along the side of the mattress, thus recovering the radiation heat escaping through the side boundaries, helped providing more uniform temperature fields.

An overview of recent applications of computational modelling in neonatology.

This paper reviews some of our recent applications of computational fluid dynamics (CFD) to model heat and mass transfer problems in neonatology and investigates the major heat and mass-transfer mechanisms taking place in medical devices, such as incubators, radiant warmers and oxygen hoods. It is shown that CFD simulations are very flexible tools that can take into account all modes of heat transfer in assisting neonatal care and improving the design of medical devices.

Modelling of heat and mass transfer processes in neonatology.

This paper reviews some of our recent applications of computational fluid dynamics (CFD) to model heat and mass transfer problems in neonatology and investigates the major heat and mass transfer mechanisms taking place in medical devices such as incubators and oxygen hoods. This includes novel mathematical developments giving rise to a supplementary model, entitled infant heat balance module, which has been fully integrated with the CFD solver and its graphical interface. The numerical simulations are validated through comparison tests with experimental results from the medical literature. It is shown that CFD simulations are very flexible tools that can take into account all modes of heat transfer in assisting neonatal care and the improved design of medical devices.

A combined study of heat and mass transfer in an infant incubator with an overhead screen.

The main objective of this study is to investigate the major physical processes taking place inside an infant incubator, before and after modifications have been made to its interior chamber. The modification involves the addition of an overhead screen to decrease radiation heat losses from the infant placed inside the incubator. The present study investigates the effect of these modifications on the convective heat flux from the infant's body to the surrounding environment inside the incubator. A combined analysis of airflow and heat transfer due to conduction, convection, radiation and evaporation has been performed, in order to calculate the temperature and velocity fields inside the incubator before and after the design modification. Due to the geometrical complexity of the model, computer-aided design (CAD) applications were used to generate a computer-based model. All numerical calculations have been performed using the commercial computational fluid dynamics (CFD) package FLUENT, together with in-house routines used for managing purposes and user-defined functions (UDFs) which extend the basic solver capabilities. Numerical calculations have been performed for three different air inlet temperatures: 32, 34 and 36 degrees C. The study shows a decrease of the radiative and convective heat losses when the overhead screen is present. The results obtained were numerically verified as well as compared with results available in the literature from investigations of dry heat losses from infant manikins.