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1.
BMJ Open ; 9(10): e030726, 2019 10 28.
Artigo em Inglês | MEDLINE | ID: mdl-31662377

RESUMO

INTRODUCTION: Patient-reported outcome-based symptom monitoring and alerting have been attractive for patient care after a tumour-removal surgery. However, the implementation parameters of this patient-centred symptom management system in perioperative patients with lung cancer are still lacking. We aim to develop a perioperative symptom scale (PSS) for monitoring, to determine the optimal time points for symptom assessment and to define the alert thresholds for medical intervention. METHODS AND ANALYSIS: This study will prospectively recruit 300 patients undergoing lung cancer surgery in six hospitals. The MD Anderson Symptom Inventory-Lung Cancer Module (MDASI-LC) is used to collect longitudinal symptom data preoperatively, daily postoperatively during in-hospital stay and weekly after discharge until 4 weeks or the start of postoperative oncological therapy. Symptoms that change significantly over time will be generated as the PSS. We will determine the optimal time points for follow-up using the generalised linear mixed-effects models. The MDASI-LC interference-measured functional status will be used as the anchor for the alert thresholds. ETHICS AND DISSEMINATION: Ethics Committee of Sichuan Cancer Hospital approved this study on 16 October 2017 (No. SCCHEC-02-2017-042). The manuscript is based on the latest protocol of Version 3.0, 15 September 2019. The results of this study will be presented at medical conferences and published in peer-reviewed journals. TRIALS REGISTRATION NUMBER: NCT03341377.


Assuntos
Neoplasias Pulmonares/cirurgia , Medidas de Resultados Relatados pelo Paciente , Assistência Perioperatória/métodos , Complicações Pós-Operatórias/diagnóstico , Estudos de Coortes , Dispneia/diagnóstico , Dispneia/fisiopatologia , Dispneia/terapia , Fadiga/diagnóstico , Fadiga/fisiopatologia , Fadiga/terapia , Humanos , Neoplasias Pulmonares/fisiopatologia , Dor Pós-Operatória/diagnóstico , Dor Pós-Operatória/fisiopatologia , Dor Pós-Operatória/terapia , Complicações Pós-Operatórias/fisiopatologia , Complicações Pós-Operatórias/terapia , Estudos Prospectivos , Reprodutibilidade dos Testes , Avaliação de Sintomas
2.
BMJ Open ; 9(8): e030041, 2019 08 26.
Artigo em Inglês | MEDLINE | ID: mdl-31455710

RESUMO

INTRODUCTION: Surgery is one of the primary treatments for lung cancer. The postoperative symptom burden experienced by patients with lung cancer is substantial, seriously delaying their recovery from surgery and impairing their quality of life. Patient-reported outcome (PRO)-based symptom management is increasingly regarded as an optimal model for patient-centred care. Currently, clinical trial-based evidence involving early-phase (immediately after surgery for up to 1 month) symptom management of lung cancer is lacking. We propose a randomised trial to evaluate the effect of a PRO-based symptom-monitoring programme with overthreshold alerts and responses for postoperative recovery in patients with lung cancer. METHODS AND ANALYSIS: The study will recruit 160 patients with lung cancer from six hospitals. The patients will be randomly allocated to the intervention group or control group in a ratio of 1:1. Patients in the intervention group will receive PRO-based symptom management from the specialists when their reported target symptom (pain, coughing, fatigue, disturbed sleep and shortness of breath) scores reach the preset threshold (score ≥4). Patients in the control group will not generate alerts and will follow the standard procedures for symptom management. All patients will receive symptom assessments via the MD Anderson Symptom Inventory-lung cancer module on the day before surgery, daily after surgery and twice a week after discharge until 4 weeks or the start of postoperative oncological treatment. The primary outcome-mean symptom threshold events-will be compared between the intervention and control group via independent sample Student's t-test. ETHICS AND DISSEMINATION: The study was approved by the Ethics Committee of Sichuan Cancer Hospital on 22 November 2018 (No. SCCHEC-02-2018-045). This manuscript is based on V.2.0, 9 May 2019 of the protocol. The study results will be disseminated in publications in peer-reviewed journals and presentations at academic conferences. TRIALS REGISTRATION NUMBER: ChiCTR1900020846.


Assuntos
Neoplasias Pulmonares/cirurgia , Medidas de Resultados Relatados pelo Paciente , Qualidade de Vida , China , Gerenciamento Clínico , Humanos , Neoplasias Pulmonares/fisiopatologia , Neoplasias Pulmonares/psicologia , Estudos Multicêntricos como Assunto , Período Pós-Operatório , Ensaios Clínicos Controlados Aleatórios como Assunto , Índice de Gravidade de Doença , Carga Tumoral
3.
Acta Crystallogr C ; 64(Pt 3): o142-4, 2008 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-18322340

RESUMO

In the title compound, C(22)H(18)N(4).2H(2)O, the organic fragment lies across a centre of inversion in the P2(1)/n space group. The water molecules form C(2)-type hydrogen-bonded chains which are linked to the 1,4-bis(1H-benzimidazol-1-ylmethyl)benzene molecules through O-H...N hydrogen bonds, forming sheets reinforced by pi-pi stacking interactions between the aromatic rings within the layers.

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