What do the conflicting findings in the trem2 transgenetic mouse model tell us? A systematic review of the role of TREM2 in Alzheimer's disease.

BACKGROUND: Given the established genetic linkage between triggering receptors expressed on myeloid cells 2 (TREM2) and Alzheimer's disease (AD), an expanding research body has delved into the intricate role of TREM2 within the AD context. However, a conflicting landscape of outcomes has emerged from both in vivo and in vitro investigations. This study aimed to elucidate the multifaceted nuances and gain a clearer comprehension of the role of TREM2. METHODS: PubMed database was searched spanning from its inception to January 2022. The search criteria took the form of ("Alzheimer's disease" OR "AD") AND ("transgenic mice model" OR "transgenic mouse model") AND ("Triggering receptor expressed on myeloid cells" OR "TREM2"). Inclusion criteria consisted of the following: (1) publication of original studies in English; (2) utilization of transgenic mouse models for AD research; and (3) reports addressing the subject of TREM2. RESULTS: A total of 43 eligible articles were identified. Our analysis addresses four pivotal queries concerning the interrelation of TREM2 with microglial function, Aß accumulation, tau pathology, and inflammatory processes. However, the diverse inquiries posed yielded inconsistent responses. Nevertheless, the inconsistent roles of TREM2 within these AD mouse models potentially hinge upon factors such as age, sex, brain region, model type, and detection methodologies. CONCLUSIONS: This review substantiates the evolving understanding of TREM2's disease progression-dependent impacts. Furthermore, it reviews the interplay between TREM2 and its effects across diverse tissues and temporal stages.

Investigation on the Strengthening Mechanism of Flow Control Extrusion by Using Experiment and Numerical Simulation.

Bimodal grain structure leads to high strength and strain hardening effect of metallic materials. In this study, an effective approach called flow control extrusion (FCE) is proposed to achieve heterostructures of pure copper. Compared with conventional extrusion (CE), FCE shows much stronger grain refine ability and much weaker grain orientation concentration. The significant grain refinement and heterostructures depend on the severe shear strain from FCE. The heterostructures of sample subject to FCE transfer from bimodal structure to gradient structure with the decrease of temperature, as the grains in the surface of sample are all refined to ultrafine scale. Both these two heterostructures can realize the improvement of strength and strain hardening effect simultaneously.