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1.
Int J Biol Macromol ; 269(Pt 2): 131878, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38692530

RESUMO

Excessive accumulation of exudate from wounds often causes infection and hinders skin regeneration. To handle wound exudate quickly and prevent infection, we developed an antibacterial Janus nanofibrous dressing with a unidirectional water-transport function. The dressing consists of a hydrophilic chitosan aerogel (CS-A) as the outer layer and a hydrophobic laurylated chitosan (La-CS) nanofibrous membrane as the inner layer. These dressings achieved excellent liquid absorption performance (2987.8 ±â€¯123.5 %), air and moisture permeability (997.8 ±â€¯23.1 g/m2/day) and mechanical strength (5.1 ±â€¯2.6 MPa). This performance was obtained by adjusting the density of CS-A and the thickness of the La-CS membrane. Moreover, the dressing did not induce significant toxicity to cells and can prevent bacterial aggregation and infection at the wound site. Animal experiments showed that the dressing can shorten the inflammatory phase, enhance blood vessel generation, and accelerate collagen deposition, thus promoting wound healing. Overall, these results suggest that this Janus dressing is a promising material for clinical wound care.


Assuntos
Antibacterianos , Bandagens , Quitosana , Nanofibras , Água , Cicatrização , Quitosana/química , Quitosana/farmacologia , Cicatrização/efeitos dos fármacos , Nanofibras/química , Antibacterianos/farmacologia , Antibacterianos/química , Animais , Água/química , Camundongos , Interações Hidrofóbicas e Hidrofílicas , Permeabilidade , Ratos , Staphylococcus aureus/efeitos dos fármacos , Masculino
2.
Int J Biol Macromol ; 230: 123158, 2023 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-36610582

RESUMO

Local hemostats still face obstacles to efficiently achieving hemostasis and promoting wound healing. Herein, a series of multifunctional well-degradable hemostatic sponges based-on carboxymethylated yeast ß-glucan (CMYG) were fabricated by lyophilization. The porous CMYG sponge not only could absorb blood quickly (44.12 g/g), but also possessed unexpected tissue adhesion (∼30 kPa), and it represented good biocompatibility in vitro on fibroblasts and red blood cells. Notably, compared with the commercial Celox™, the CMYG sponge achieved more rapid hemostasis and significantly reduced blood loss in liver injury rat models by rapid wound block. Interestingly, the developed sponge showed an outstanding effect on antioxidant, anti-infection, anti-inflammatory, and cell proliferation, which are beneficial for further wound repair. Overall, these results suggest that the CMYG sponge is a promising candidate for the clinical management of uncontrollable hemorrhage and the further development of wound dressing materials throughout skin defect repair.


Assuntos
Hemostáticos , Saccharomyces cerevisiae , Ratos , Animais , Adesivos/farmacologia , Hemostasia , Hemostáticos/farmacologia , Hemorragia/tratamento farmacológico , Bandagens , Anti-Inflamatórios/farmacologia , Antibacterianos/farmacologia
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