TsCl promoted deoxygenative phosphorothiolation of quinoline N-oxides towards S-quinolyl phosphorothioates.

A convenient, efficient and practical approach for the synthesis of S-quinolyl phosphorothioates via cheap TsCl promoted deoxygenative C2-H phosphorothiolation of quinoline N-oxides with readily available triethylammonium O,O-dialkylphosphorothioates was developed. The reaction performed well under transition-metal-free conditions at room temperature with a very short reaction time (10-20 min). Preliminary studies showed that the current transformation underwent a nucleophilic substitution process.

Traditional Chinese Medicine Recognition Based on Target Detection.

Traditional Chinese medicine (TCM) is widely used in China, but the large variety can easily lead to difficulties in visual identification. This study aims to evaluate the availability of target detection models to identify TCMs. We have collected images of 100 common TCMs in pharmacies, and use three current mainstream target detection models: Faster RCNN, SSD, and YOLO v5 to train the TCM dataset. By comparing the metrics of the three models, the results show that the YOLO v5 model has obvious advantages in the recognition of a variety of TCM, the mean average accuracy of the YOLO v5 is 94.33% and the FPS has reached 75, this model has a smaller number of parameters and solves the problem of detection and occlusion for small targets. Our experiments prove that the target detection technology has broad application prospects in the detection of TCM.

Comparison of RetinaNet, SSD, and YOLO v3 for real-time pill identification.

BACKGROUND: The correct identification of pills is very important to ensure the safe administration of drugs to patients. Here, we use three current mainstream object detection models, namely RetinaNet, Single Shot Multi-Box Detector (SSD), and You Only Look Once v3(YOLO v3), to identify pills and compare the associated performance. METHODS: In this paper, we introduce the basic principles of three object detection models. We trained each algorithm on a pill image dataset and analyzed the performance of the three models to determine the best pill recognition model. The models were then used to detect difficult samples and we compared the results. RESULTS: The mean average precision (MAP) of RetinaNet reached 82.89%, but the frames per second (FPS) is only one third of YOLO v3, which makes it difficult to achieve real-time performance. SSD does not perform as well on the indicators of MAP and FPS. Although the MAP of YOLO v3 is slightly lower than the others (80.69%), it has a significant advantage in terms of detection speed. YOLO v3 also performed better when tasked with hard sample detection, and therefore the model is more suitable for deployment in hospital equipment. CONCLUSION: Our study reveals that object detection can be applied for real-time pill identification in a hospital pharmacy, and YOLO v3 exhibits an advantage in detection speed while maintaining a satisfactory MAP.

Women's perceptions of their husband's drinking behavior as a risk factor of their health-related quality of life in the postpartum period.

PURPOSE: The objective of this study is to investigate the association between women's perceptions of their husband's drinking behavior and their health-related quality of life (HRQOL) in the postpartum period. METHODS: We used multistage stratified systematic sampling to recruit 24,200 pairs, postpartum women and newborns, from the Taiwan national birth register in 2005. A structured questionnaire to assess lifestyle risk behaviors and HRQOL was successfully administered to 87.8% of the sampled population. Subjects undertook a home interview 6 months after their deliveries between June 2005 and July 2006. The Medical Outcomes Study 36-item Short-Form (SF-36) was used to measure the HRQOL of the wives, and the scores were used to look for associations with their perceptions of husband's alcohol-drinking behavior. RESULTS: After controlling for the potential confounders, wives' scores on all SF-36 scales except the PF scale were inversely associated with the frequency of their husbands' alcohol drinking. Moreover, the MCS measure was also inversely associated with in the frequency of their husbands' alcohol drinking but the PCS did not show any association. CONCLUSIONS: Our study adds evidence supporting the negative association between of husbands' alcohol drinking and their wives' health as measured by the SF-36 HRQOL, especially for mental health.