RESUMO
BACKGROUND: Tranexamic acid (TA) is a traditional plasmin inhibitor, and its role in the renovation of damaged skin has become the topic of a lot of research. The aim of this study is to determine whether TA could repair the skin barrier by means of tight intercellular junctions. METHODS: Two kinds of damaged skin models were set up and subjected to repeated application of sodium lauryl sulfate and irradiation of ultraviolet B. Through bioengineering technology and immunohistochemistry tests, TA-induced changes in skin were detected. RESULTS: After 1, 3, 7, and 14 days of application, TA can significantly accelerate barrier recovery and decrease the melanin index values of ultraviolet B irritation skin. The mean optic density of occludin from TA treatment is higher than from self-repair. CONCLUSION: These experiments suggest that TA can accelerate skin barrier recovery and upregulate occludin induced by physicochemical damages of human skin, but it is advisable to perform more research on the upregulation of occludin in molecular mechanism in the future.
Assuntos
Antifibrinolíticos/farmacologia , Fenômenos Fisiológicos da Pele/efeitos dos fármacos , Pele/efeitos dos fármacos , Ácido Tranexâmico/farmacologia , Cicatrização/efeitos dos fármacos , Adulto , Idoso , Eritema/tratamento farmacológico , Eritema/etiologia , Feminino , Humanos , Masculino , Melaninas/análise , Pessoa de Meia-Idade , Ocludina/análise , Lesões por Radiação/tratamento farmacológico , Lesões por Radiação/etiologia , Pele/química , Pele/efeitos da radiação , Dodecilsulfato de Sódio/farmacologia , Junções Íntimas/efeitos dos fármacos , Raios Ultravioleta/efeitos adversos , Regulação para Cima/efeitos dos fármacos , Cicatrização/fisiologia , Adulto JovemRESUMO
BACKGROUND/PURPOSE: Cigarette smoking not only causes systemic health problems, but may also be an underlying cause of premature skin aging. Cigarette smokers frequently have morphological changes in facial skin that may be attributed to reduced oxygen in this region. The purpose of this study was to measure the oxygen content in facial skin before and after smoking. METHODS: Twenty-five volunteers participated in this study. Changes in oxygen content of the facial skin were measured before and after 30 min of cigarette smoking. Skin temperature and oxygen content were evaluated in the periorbital and periolar regions. RESULTS: There was a significant increase in temperature after smoking. The oxy hemoglobin and partial pressure of oxygen decreased in both the periocular and perioral areas after smoking. There were no changes in deoxy hemoglobin and partial pressure of carbon dioxide at these areas. CONCLUSION: Significant changes were seen in temperature and oxygen content after only 30 min of smoking. The results from this study suggest that alterations in the skin temperature and oxygen content in facial skin after smoking may be an underlying cause of premature skin aging.
Assuntos
Face/fisiopatologia , Oximetria/métodos , Oxigênio/metabolismo , Pele/metabolismo , Fumar/metabolismo , Adulto , Humanos , Masculino , Pessoa de Meia-Idade , Consumo de Oxigênio , Distribuição TecidualRESUMO
PURPOSE: To observe the alteration ultraviolet radiation (UVR) of skin's tolerance after its exposure to the small dose of UVR under the protection of sunscreen. METHODS: Eleven subjects who applied sunscreen were exposed to 0.75 dose minimal persistent pigment darkening (MPPD) and minimal erythema dose (MED) by the Phototherapy Unit for 4 weeks. Each week their MPPDs and MEDs were measured by solar simulator. Meanwhile, SPECTCOLOMETER® and VISIOSCAN VC98® were used to detect the test areas and control areas. RESULTS: The values of MPPD and MED increased significantly after the exposure to UVR. But there were no visible changes on the surface of skin's texture. CONCLUSION: With the protection of sunscreen, the UVR tolerance of skin was greatly increased after the skin's exposure to the small dose UV.
