1.
Org Lett
; 9(12): 2421-3, 2007 Jun 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17503843
RESUMO
A facile and efficient one-pot synthesis of highly substituted pyridin-2(1H)-ones is developed via the Vilsmeier-Haack reaction of readily available 1-acetyl,1-carbamoyl cyclopropanes, and a mechanism involving sequential ring-opening, haloformylation, and intramolecular nucleophilic cyclization reactions is proposed.