RESUMO
OBJECTIVE: To observe the changes of vascular endothelial functions and general neuro-endocrine-immunity (NEI) network under the state of qi-deficiency syndrome induced by excessive idleness and to approach their internal relevance and illuminate initially the pathophysiological mechanism of vascular lesion induced by excessive idleness. METHODS: A total of 100 male Wistar rats were randomly divided into the control group and the qi-deficiency syndrome model group, 50 rats in each group. The qi-deficiency syndrome model was established by feeding the animals with hyper-alimentation diet in combination with restricting movement for 10 weeks. Changes of common chemical signal molecules related to NEI and vascular endothelial functions were measured by the end of the experiment. Furthermore, their internal relevance was analyzed by the method of canonical correlation analysis. RESULTS: The vascular endothelial structure and function were obviously injured in the model group. Compared with the control group, the chemical signal molecules, such as 5-hydroxytryptamine (5-HT), corticosterone (CORT), triiodothyronine (T3), tetraiodothyronine (T4), angiotensin II (Ang II), interleukin-1 (IL-1), and tumor necrosis factor-alpha (TNF-alpha) in peripheral blood of the model group (n=43) were changed significantly (P<0.05 or P<0.01). Canonical correlation analysis showed that vascular endothelial dysfunction was correlated to the changes of these signal molecules in the NEI network. CONCLUSIONS: Comfort-based lifestyle induced not only vascular endothelial dysfunction but also an imbalance of the NEI network. Vascular endothelial dysfunction and the imbalanced NEI network interacted with each other, and an imbalance of the NEI network may be the pathophysiologic basis for the genesis and development of vascular endothelial dysfunction, even diseases of the blood vessel.
Assuntos
Doenças Cardiovasculares/etiologia , Endotélio Vascular/fisiopatologia , Sistema Imunitário/fisiologia , Neuroimunomodulação/fisiologia , Sistemas Neurossecretores/fisiologia , Comportamento Sedentário , Animais , Aorta/metabolismo , Aorta/patologia , Aorta/fisiopatologia , Aorta/ultraestrutura , Biomarcadores/análise , Biomarcadores/metabolismo , Doenças Cardiovasculares/metabolismo , Doenças Cardiovasculares/patologia , Doenças Cardiovasculares/fisiopatologia , Modelos Animais de Doenças , Endotelinas/metabolismo , Endotélio Vascular/metabolismo , Endotélio Vascular/patologia , Sistema Imunitário/metabolismo , Sistema Imunitário/patologia , Masculino , Sistemas Neurossecretores/metabolismo , Sistemas Neurossecretores/patologia , Óxido Nítrico/metabolismo , Qi , Ratos , Ratos Wistar , Síndrome , Deficiência da Energia Yin/etiologia , Deficiência da Energia Yin/metabolismo , Deficiência da Energia Yin/patologia , Deficiência da Energia Yin/fisiopatologiaRESUMO
672 specimens of entomogenous fungi belonging to 20 species, 8 genera and 4 families were collected from 20 sampling quadrates in the Langya Mountains Nature Reserve of East Anhui. The dominant species were Beauveria bassiana, Paecilomyces farinosus, P. cateinannulatus, B. brongniartii and P. fumosoroseus, and B. bassiana was most dominant, with the relative abundance of 73.8%. The entomogenous fungi in the Reserve were high in amount but low in diversity. The amount of isolates and the abundance of each species were the highest in summer and decreased with decreasing air temperature and rainfall, while the Pielou evenness changed from relatively low to relatively high. Paecilomyces spp. had a less seasonal fluctuation of quantity than Beauveria spp.