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Exp Biol Med (Maywood)
; 244(8): 621-629, 2019 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30836793
RESUMO
IMPACT STATEMENT: Bax induces mitochondria-dependent programed cell death. While cytotoxic drugs activating Bax have been developed for cancer treatment, clinically effective therapeutics suppressing Bax-induced cell death rescuing essential cells have not been developed. This mini-review will summarize previously reported Bax inhibitors including peptides, small compounds, and antibodies. We will discuss potential applications and the future direction of these Bax inhibitors.