RESUMO
Forty-one chemical company workers had chloracne as a result of exposure to 3,4,3',4'-tetrachloroazoxybenzene (TCAB), an extraneous intermediate produced during the manufacture of a new herbicide. There was no laboratory evidence of significant hepatotoxicity or porphyria during the short time the herbicide was produced. An acnegenic when applied to the rabbit ear, TCAB is also a potent inducer of the microsomal enzyme aryl hydrocarbon hydroxylase. Prevention of chlorance is a difficult industrial engineering task and treatment of the disease is even more perplexing.
Assuntos
Acne Vulgar/induzido quimicamente , Compostos Azo/efeitos adversos , Clorobenzenos/efeitos adversos , Herbicidas/efeitos adversos , Animais , Indústria Química , Dermatite Ocupacional/etiologia , Humanos , Oxigenases de Função Mista/metabolismo , Medicina do Trabalho , Coelhos , Pele/patologiaRESUMO
Familial scleroderma is rare; only seven documented instances of the disease have been reported, to our knowledge. This report adds two more families to the literature. Three children in one family and two in the other had clinically and histiologically established localized scleroderma.
