1.
Chem Commun (Camb)
; 53(94): 12704-12707, 2017 Nov 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29136072
RESUMO
The possibility to sequence cytotoxic O6-alkylG DNA adducts would greatly benefit research. Recently we reported a benzimidazole-derived nucleotide that is selectively incorporated opposite the damaged site by a mutated DNA polymerase. Here we provide the structural basis for this reaction which may spur future developments in DNA damage sequencing.