Influence of the in situ component in 389 infiltrating ductal breast carcinomas.

BACKGROUND: Our aim was to evaluate and compare lymph node involvement, as well as disease-free survival (DFS) and overall survival (OS), between infiltrating ductal carcinoma with (group 1) and without (group 2) intraductal carcinoma component in order to determine the prognostic value of the intraductal component. METHODS: Data from 389 cases of infiltrating ductal carcinoma of the breast were included in the study by means of reviewing medical charts and pathology slides. RESULTS: There was no statistically significant difference between both groups regarding node status. The 5-year DFS rate was 90.7% in group 1 and 81.8% in group 2 (p = 0.014), with a median follow-up of 73.2 months (95% CI 68.3-77.4). There was no statistically significant difference in 5-year OS between groups (98% group 1 vs. 93% group 2) with a median global survival of 134 months (95% CI 131-137). CONCLUSIONS: The presence of intraductal component in the infiltrating carcinoma seems to increase DFS and may be an independent and favorable prognostic factor for breast cancer.

[Pelvic actinomycosis in menopausal patient, case review]. / Actinomicosis pélvica en paciente menopáusica. Presentación de un caso.

Pelvic actinomycosis is a granulomatous chronic illness due to anaerobic, gram-positive, branching filamentous bacteria (Actinomyces israelii), this and other species of actinomyces occur in the normal flora of the gastrointestinal and genital tract in humans. Infection is associated in women using an IUD (Intrauterine device) for long periods and it has the characteristic of simulate malignant diseases causing most of the times wrong preoperative diagnosis. We analyzed a postmenopausal patient who was treated surgically without specific diagnosis, then by anatomo-pathologic study of the specimen the result was actinomycosis. The main purpose to obtain the correct preoperative diagnosis is because we have to use antibiotics in the treatment and it may reduce the frequency of radical surgeries.

[Prevalence of Chlamydia trachomatis infection, as evaluated by molecular biology methods]. / Prevalencia de infección por Chlamydia trachomatis determinada mediante métodos de biología molecular.

BACKGROUND: To determine the prevalence of Chlamydia trachomatis infection in our area by molecular methods. METHODS: We describe the combined results of three studies carried out in the city of Barcelona including a total of 408 women considered to be at high risk for acquiring a sexually transmitted disease (STD). The first study was performed in 94 women attended at a public STD clinic located downtown, the second in 112 women attended at the Hospital Clinic and the third in 202 women attended at Hospital Vall d'Hebron (both third-level hospitals). In the first and third study endocervical exudate was tested with a PCR technique, and in the second study LCR was performed in 20-ml urine samples. RESULTS: Chlamydia trachomatis was detected in 1 woman in the first study, in no women in the second and in 3 women in the third. The prevalence of Chlamydia trachomatis infection detected in the three studies using molecular biology techniques was 1.06%, 0% and 1.48% respectively, giving an overall prevalence of 0.98%. CONCLUSION: The prevalence of Chlamydia trachomatis infection in our geographic area is surprisingly low.

Prevalencia de infección por Chlamydia trachomatis determinada mediante métodos de biología molecular / Prevalence of Chlamydia trachomatis infection, as evaluated by molecular biology methods

FUNDAMENTO. Determinar la prevalencia de la infección por Chlamydia trachomatis por métodos moleculares. MÉTODOS. Se describen conjuntamente los resultados de 3 trabajos realizados en la ciudad de Barcelona y en los que se estudiaron 408 mujeres consideradas como de alto riesgo para la adquisición de una enfermedad de transmisión sexual (ETS). El primer estudio incluyó a 94 mujeres atendidas en un centro público de ETS, el segundo a 112 mujeres atendidas en el Hospital Clínico y el tercero a 202 mujeres atendidas en el Hospital Vall d'Hebron de Barcelona. En el primer y tercer estudio se practicó toma endocervical y se realizó una técnica de reacción en cadena de la polimerasa (PCR). En el segundo se realizó reacción en cadena de la ligasa (LCR) a partir del primer chorro de orina. RESULTADOS. Chlamydia trachomatis se detectó en una sola paciente en el primer estudio, en ninguna en el segundo y en 3 pacientes en el tercero. Es decir que utilizando técnicas de biología molecular las prevalencias de infección por Chlamydia trachomatis fueron del 1,06, 0 y 1,48 por ciento, respectivamente, siendo la prevalencia total del 0,98 por ciento. CONCLUSIONES. La prevalencia de la infección por Chlamydia trachomatis en nuestra área geográfica es sorprendentemente baja (AU)