Residue-Free Orally Administered Drug Carrier Based on a Porous Aromatic Framework for Efficient Multisite Treatment.

Nowadays, oral medications are the primary method of treating disease due to their convenience, low cost, and safety, without the need for complex medical procedures. To maximize treatment effectiveness, almost all oral medications utilize drug carriers, such as capsules, liposomes, and sugar coatings. However, these carriers rely on dissolution or fragmentation to achieve drug release, which leads to drugs and carriers coabsorption in the body, causing unnecessary adverse drug reactions, such as nausea, vomiting, abdominal pain, and even death caused by allergy. Therefore, the ideal oral drug carrier should avoid degradation and absorption and be totally excreted after drug release at the desired location. Herein, a gastrointestinally stable oral drug carrier based on porous aromatic framework-1 (PAF-1) is constructed, and it is modified with famotidine (a well-known gastric drug) and mesalazine (a well-known ulcerative colitis drug) to verify the excellent potential of PAF-1. The results demonstrate that PAF-1 can accurately release famotidine in stomach, mesalazine in the intestine, and finally be completely excreted from the body without any residue after 12 h. The use of PAF materials for the construction of oral drug carriers with no residue in the gastrointestinal tract provides a new approach for efficient disease treatment.

Biological Application of Porous Aromatic Frameworks: State of the Art and Opportunities.

Porous aromatic frameworks (PAFs) were first reported in 2009 and have quickly attracted much attention because of their exceptionally ultrahigh specific surface area (5800 m2·g-1). Uniquely, PAFs are constructed from carbon-carbon-bond-linked aromatic-based building units, which render PAFs extremely stable in various environments. At present, PAFs have been applied in many fields, such as adsorption, catalysis, ion exchange, electrochemistry, and so on. However, for such a unique material, its application in the biological fields is still rarely explored. Therefore, this Perspective introduces the reported application of PAFs in biological fields, for instance, diagnosis and treatment of diseases, artificial enzymes, drug delivery, and extraction of bioactive substances. Major challenges and opportunities for future research on PAFs in biology and biomedicine are identified in diagnostic platforms, novel drug carriers/antidotes, and novel artificial enzymes.