Mid-infrared absorption spectroscopy and differential damage in vitro between lipids and proteins by an all-fiber-integrated supercontinuum laser.

We identify and differentially damage lipids and proteins using wavelengths between 2.6 and 3.8 mum from a fiber-based supercontinuum (SC) laser. Absorption spectroscopy of the constituents of normal artery and atherosclerotic plaque, including adipose tissue, macrophages and foam cells, are measured by a SC laser in the mid-infrared. By using the laser light within the C-H fatty acid and cholesterol esters absorption band, we also demonstrate differential damage of lipid-rich adipose tissue without damaging the protein-rich blood vessel wall. The experiments use a novel SC laser that is all-fiber-integrated with no moving parts, covers a continuous spectrum ranging from approximately 0.8 to beyond 4.2 microm, and outputs a time-averaged power scalable up to 10.5 W.

Power adjustable visible supercontinuum generation using amplified nanosecond gain-switched laser diode.

Supercontinuum (SC) light with a continuous spectrum covering 0.45-1.2 microm is scaled from 250-740 mW by varying the repetition rate of an amplified, frequency doubled, telecom laser diode. Efficient SC generation requires minimal non-linearity in the amplifier and anomalous dispersion pumping close to the fiber zero dispersion wavelength. Based on simulations, we present a 2-stage design that separates pulse break-up from spectral broadening to enhance the SC bandwidth for quasi-CW pumping.

Power scalable mid-infrared supercontinuum generation in ZBLAN fluoride fibers with up to 1.3 watts time-averaged power.

Mid-infrared supercontinuum (SC) extending to ~4.0 mum is generated with 1.3 W time-averaged power, the highest power to our knowledge, in ZBLAN (ZrF(4)-BaF(2)-LaF(3)-AlF(3)-NaF...) fluoride fiber by using cladding-pumped fiber amplifiers and modulated laser diode pulses. We demonstrate the scalability of the SC average power by varying the pump pulse repetition rate while maintaining the similar peak power. Simulation results obtained by solving the generalized nonlinear Schrödinger equation show that the long wavelength edge of the SC is primarily determined by the peak pump power in the ZBLAN fiber.

Mid-infrared supercontinuum generation to 4.5 microm in ZBLAN fluoride fibers by nanosecond diode pumping.

A mid-infrared supercontinuum (SC) is generated in ZBLAN (ZrF4-BaF2-LaF3-AlF3-NaF...) fluoride fibers from amplified nanosecond laser diode pulses with a continuous spectrum from approximately 0.8 microm to beyond 4.5 microm. The SC has an average power of approximately 23 mW, a pump-to-SC power conversion efficiency exceeding 50%, and a spectral power density of approximately -20 dBm/nm over a large fraction of the spectrum. The SC generation is initiated by the breakup of nanosecond laser diode pulses into femtosecond pulses through modulation instability, and the spectrum is then broadened primarily through fiber nonlinearities in approximately 2-7 m lengths of ZBLAN fiber. The SC long-wavelength edge is consistent with the intrinsic ZBLAN material absorption.

Third order cascaded Raman wavelength shifting in chalcogenide fibers and determination of Raman gain coefficient.

Cascaded Raman wavelength shifting up to three orders from 1553 nm to 1867 nm is demonstrated in As(2)S(3)-chalcogenide fibers. Due to a long zero dispersion wavelength for the sulfide fiber (>4.5 mum), pumping the fiber at 1553 nm results in generation of cascaded Stokes orders based on stimulated Raman scattering. Using the threshold power for the Raman orders, we estimate the Raman gain coefficient for the As(2)S(3) fibers to be ~5.7x10(-12) m/W at 1550 nm. Observation of higher Raman orders is limited by damage to the fiber at input intensities >1 GW/cm(2).